The roleWe are seeking a highly motivated Scientist to support the development and scale-up of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on process optimization and scale-up of targeted LNPs encapsulating modified DNA and cofactor mRNA, while also contributing to research efforts aimed at improving LNP design and performance.
This is an ideal opportunity for a scientist with a strong background in process development who is interested in expanding into formulation development and early-stage R&D, including formulation screening and optimization of next-generation LNP systems.
The successful candidate will work collaboratively within cross-functional teams to advance LNP platform capabilities and support the development of scalable and robust nucleic acid delivery systems.
Key responsibilities- Support process development and optimization activities for LNP formulation and scale-up, including mixing parameters, encapsulation efficiency, and reproducibility.
- Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA.
- Collaborate with internal and external teams to support characterization and evaluation of LNP formulations.
- Assist with technology transfer and scale-up activities, including coordination with external partners or internal manufacturing teams.
- Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams.
- Stay current with advancements in LNP technologies and nucleic acid delivery approaches.
Professional experience and qualifications- PhD. in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related field, with 3+ years of relevant industry experience; M.S. with 8+ years of experience; or Bachelor with 10+ years of experience.
- Strong background in process development, scale-up, or manufacturing of nanoparticle or LNP-based systems.
- Experience working with nucleic acid formulations (e.g., mRNA, DNA) is highly preferred.
- Familiarity with T mixing, or similar, formulation scale-up, and characterization techniques (e.g., DLS, encapsulation assays).
- Demonstrated ability to design experiments, analyze data, and solve complex technical problems.
- Strong communication and collaboration skills.
What We Offer- Opportunity to work at the forefront of LNP formulation innovation
- Collaborative, science-driven culture with high impact research
- Competitive compensation and benefits package
The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.
