Position Purpose:The Senior Scientist will work collaboratively across the Research organization to support preclinical efforts in understanding the target engagement, pharmacology, and efficacy of novel compounds in disease models. This position requires a scientist with experience designing and executing thoughtful in vivo studies and developing assays to establish and investigate preclinical biomarkers in tissue samples. This position will report into the Executive Director of in vivo pharmacology.
Key Responsibilities:- Support the in vivo characterization of novel compounds by designing and conducting in life studies and performing molecular analysis with a combination of internal and outsourced resources.
- Work collaboratively across functions to support programs through preclinical proof of concept and candidate selection to advance the company pipeline.
- Use a high level of scientific judgment to adapt and/or create standard methods and techniques by applying breadth of knowledge and prior work experience.
- Develop and optimize preclinical biomarker assays to support discovery efforts and bridge into early development activities.
- Maintain excellent and timely recordkeeping while adhering to aggressive timelines
- Author study reports that may be used for regulatory filings and scientific manuscripts.
Required Skills & Experience: - Bachelor's degree with 16+ years of experience, or Master's degree with 10+ years of post-graduate experience, or Ph.D with 6+ (industry experience is a plus). Degrees in Pharmacology, Neuroscience or relevant disciplines highly preferred.
- Experience with intrathecal and intracerebroventricular dosing in preclinical models
- Experience working in drug discovery with an emphasis on neurology indications, experience working with oligonucleotides is a plus.
- Designing and managing experiments at contract research organizations.
- Experience developing and optimizing assays in tissue matrix (i.e MSD, ELISA, qPCR), IHC skills a plus.
- Excellent verbal and written communication skills.
- Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
Location(s): Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a lab-based position currently based in Bedford and will later be based in Waltham.
Travel:This position will require approximately 5% travel.
Compensation and Benefits:At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.
The anticipated salary range for this role is
$154,000 - $179,000The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.
Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).
