Job Family:Scientist
Travel Required:None
Clearance Required:Ability to Obtain Public Trust
What You Will Do:We are looking for a Senior Scientist to support the operational and research objectives of the National Institute on Aging (NIA) Intramural Research Program by supporting genomic, genetics, single-cell sequencing, and spatial transcriptomics research activities. This is a full-time position located in Baltimore, MD.
- Provide on-site scientific expertise, laboratory support, and data analysis support for genomic and genetics experiments conducted by NIA research staff.
- Organize, validate, and process samples for microarray, next-generation sequencing, spatial transcriptomics, and single-cell sequencing experiments.
- Use advanced scientific knowledge and laboratory skills to resolve complex genetics and genomics issues, provide experimental guidance, and conduct pilot studies to develop and improve laboratory techniques.
- Maintain an accurate inventory of samples, reagents, and consumables through tracking systems and databases; obtain vendor quotes and assist with purchasing requests for laboratory supplies, services, and equipment.
- Perform operational troubleshooting, calibration, software updates, and maintenance of specialized laboratory instruments while ensuring compliance with laboratory safety procedures.
- Support the planning, execution, troubleshooting, and analysis of single-cell and spatial transcriptomics experiments utilizing platforms such as Chromium X and CytAssist.
- Acquire, maintain, and support specialized laboratory instrumentation and evaluate emerging technologies, software, and methodologies for potential implementation.
- Design and conduct complex scientific experiments requiring broad knowledge of molecular biology, genomics, transcriptomics, and related scientific principles.
- Provide technical support and scientific guidance to laboratory staff on research projects, experimental design, assay development, and data interpretation.
- Establish, train users on, and help manage Laboratory Information Management Systems (LIMS) and Electronic Laboratory Notebooks (ELN).
- Maintain, calibrate, troubleshoot, and train staff on laboratory instrumentation, equipment, and associated software applications.
- Manage scientific resources, including reagents, frozen cell stocks, biological samples, and research inventories.
- Conduct bioinformatics and statistical analyses and prepare data for abstracts, scientific reports, manuscripts, and presentations.
- Maintain accurate and detailed electronic laboratory notebooks and research documentation.
- Collaborate with Principal Investigators and research staff to prioritize instrument usage and optimize laboratory operations.
- Coordinate with IT personnel regarding software, data management, instrument connectivity, and technology-related issues.
- Prepare technical reports, manuscripts, abstracts, posters, oral presentations, and other scientific communications.
- Present research findings at laboratory meetings, scientific conferences, symposia, and national scientific meetings.
- Support data management and sharing initiatives, including organizing and uploading datasets to repositories such as GEO, SRA, and MassIVE.
- Provide mentoring, training, and technical guidance to fellows, postdoctoral researchers, students, biologists, and junior scientists.
- Support scientific collaborations, grant-related activities, laboratory organization initiatives, and research program development.
- Provide scientific guidance to management and laboratory leadership through literature reviews, technical evaluations, and recommendations for research activities and equipment purchases.
- Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer.
What You Will Need:- Ph.D. in Neuroscience, Biology, or a related scientific field.
- Minimum of EIGHT (8) years of experience in genomics, genetics, molecular biology, and transcriptomics research.
- Hands-on background supporting single-cell sequencing and spatial transcriptomics workflows.
- Skilled in operating, maintaining, and troubleshooting specialized scientific instrumentation.
- Background conducting bioinformatics and statistical analyses of genomic and transcriptomic datasets.
- Proven ability to prepare scientific manuscripts, technical reports, presentations, and publication-quality figures.
- Knowledge of laboratory inventory management, research documentation, and electronic records.
- Proficiency with Microsoft Office Suite.
- Ability to train, mentor, and support researchers and laboratory personnel.
- Ability to maintain detailed electronic laboratory notebooks and research records.
- Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.
What Would Be Nice To Have:- Familiarity with OLINK Explore Protein Biomarker Discovery platforms.
- Knowledge of 10X Genomics single-cell sequencing technologies.
- Strong oral and written communication skills.
- Collaborative approach to working with multidisciplinary research teams.
- Background supporting shared scientific core facilities or advanced research laboratories.
- Ability to implement or administer Laboratory Information Management Systems (LIMS).
- Skilled in managing scientific datasets and submissions to public repositories such as GEO, SRA, and MassIVE.
- Exposure to Data Management and Sharing (DMS) initiatives.
- Record of peer-reviewed publications and scientific presentations.
- Mentoring background with fellows, postdoctoral researchers, students, or junior scientists.
- Ability to evaluate and implement emerging laboratory technologies and research methodologies.
The annual salary range for this position is $130,000.00-$216,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.
What We Offer:Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
- Medical, Rx, Dental & Vision Insurance
- Personal and Family Sick Time & Company Paid Holidays
- Parental Leave
- 401(k) Retirement Plan
- Group Term Life and Travel Assistance
- Voluntary Life and AD&D Insurance
- Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
- Transit and Parking Commuter Benefits
- Short-Term & Long-Term Disability
- Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
- Employee Referral Program
- Corporate Sponsored Events & Community Outreach
- Care.com annual membership
- Employee Assistance Program
- Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
- Position may be eligible for a discretionary variable incentive bonus
