Senior Scientist, Formulation and DP Development
Sutro Biopharma, Inc. is looking for a technical leader who will report to the Executive Director of Formulation and DP Development. You will be developing new compositions for biologic / conjugated molecules and creating robust DP manufacturing processes to advance Sutro pipeline and enhance our internal and collaborative product development initiatives in a fast-paced environment.
Responsibilities:
The candidate we are seeking will work within our Formulation and DP Development team to participate in formulation and DP development for phase appropriate liquid and lyophilized formulations for intermediates, drug substance and drug products. The successful candidate will participate in activities in technology transfer to CMO's. The position is expected to design, execute, document formulation, stability and in-use/compatibility studies to support the final formulation, clinical administration and manufacturing processes. The position will utilize/implement fit-for-purpose analytical methods for biophysical characterization, formulation and process development and stability testing. This position is expected to communicate experimental data both verbally at group, department and cross functional meetings and through written documents and reports that may be included in regulatory filings.Qualifications:
- BS/MS (12+ years) or PhD (7+ years) of experience in scientific discipline (Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biomedical Engineering, or related discipline) and demonstrated scientific creativity and contributions
- Solid technical skills and experience in pre-formulation screening studies, biophysical/ biochemical characterization of proteins, analytical method development and protein/ antibody/ADC product development is essential
- Practical experience with design and execution of in-use stability studies for biologics and compatibility with administration components
- Demonstrated ability to design experiments and routinely generate new ideas and original research. High level of scientific initiative and independence. Highly autonomous requiring minimal supervision from manager.
- Analytical instrumentation such as chromatographic (HPLC, UPLC, column chromatography), visible and subvisible particle analysis, capillary electrophoresis and/or biophysical techniques (UV-vis, MALS/DLS, DSC, CD, FTIR, AUC, Fluorescence spectroscopy) for protein characterization are highly desirable.
- Able to cooperate effectively with cross functional teams, such as up and down stream process development, manufacturing and quality. Ability to quickly adapt to changes in project direction.
- Working knowledge of cGMP and relevant drug product development guidelines and regulations
- Flexibility to work on multiple projects between departments in a fast-paced environment is essential.
- Excellent oral and written communication skills and being detailed oriented are important attributes.
Sound exciting? Apply today and join our team!
Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.
The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma's California based locations will be $155,000 - $168,000 (not including bonus, equity, and benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.
