Our Analytical Development team is growing and we're seeking a Senior Research Associate to participate in designing and executing experiments, as well as perform sample analysis utilizing HPLC, CE-SDS, iCIEF, and plate-based assays. These activities will support CMC, discovery, pre-clinical, and clinical development of existing and new lead candidates. This position will directly support the discovery of next-generation immune oncology drugs. It is a hands-on position that requires effective communication and documentation of results to enable the advancement of novel research molecules toward development of clinical candidates, which will ultimately lead to late-stage development and commercialization. Ideal applicants will be agile and highly driven, collaborative, team-oriented, possess excellent communication and organization skills, and carry a strong commitment to excellence.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES- Perform HPLC and UPLC assays with minimal supervision including SEC and RP.
- Execute CE-SDS and iCIEF analysis for novel protein therapeutics and contribute to method optimization, qualification, and lifecycle management.
- Perform ELISAs for potency assessment.
- Perform DLS/SLS analysis using an UNcle instrument and generate datasets that will be used for formulation development studies.
- Perform subvisible particulate matter analysis by HIAC.
- Perform formulation development studies and execute clinical in-use stability studies, transfer formulation knowledge internally.
- Design, conduct, analyze, interpret, and report laboratory experiments; summarize results for meetings and regulatory filings.
- Write and manage SOP's and test methods.
- Manage and maintain required reagents, laboratory environment, and equipment needed to carry out assignments.
- Draft development reports, method qualification protocols, and method qualification reports
- Prepare presentations for team meetings.
- Work closely with team leaders to complete highest priority work to reach goals and milestones.
- Other duties as assigned.
REQUIRED SKILLS AND QUALIFICATIONS- Bachelor's degree and 4-6 years of relevant industry experience or a master's degree with 3-5 years of relevant industry experience.
- Strong benchtop skills, experience with analysis of protein biologics and peptides.
- Proficiency with HPLC and UPLC assays; at least 3 years of experience is required. SEC and RP are desired.
- Experience with protein characterization techniques including CE-SDS, iCIEF, or related electrophoretic methods is preferred.
- Experience performing ELISAs is desired but not necessary
- Experience supporting analytical method qualification, comparability, stability, or formulation development studies is preferred.
- Demonstrated ability to analyze complex datasets, identify trends, troubleshoot experiments, and communicate scientific conclusions effectively.
- Ability to perform routine testing and to follow SOPs in a highly accurate and reproducible manner.
- Desire and ability to learn new technologies and explore new approaches to innovate.
- Training on project specific assays and ability to train others.
- Proven experience with writing and maintaining SOPs.
- Demonstrated ability to maintain accurate, complete, and contemporaneous experimental records in ELN systems in accordance with Good Documentation Practices (GDP).
- Ability to work independently; anticipates and solves problems in a proactive fashion.
- Must have excellent computer skills, and proficiency with Microsoft Excel and PowerPoint are required.
- Good oral and written communication skills a must.
- Excellent team player.
$95,000 - $108,000 a year
In addition to a competitive base salary ranging from $95,000 to $108,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.
Job Type: Full-time
Benefits:• Annual bonus program
• Incentive stock option plan
• 401k plan with flat non-elective employer contribution
• Comprehensive medical insurance with 90-100% employer-paid premiums
• Dental and vision insurance
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
• Unlimited PTO
• Generous holiday schedule; includes summer and winter company shutdown
• Relocation assistance
Schedule:• Monday to Friday
Work authorization:• United States (Required)
Additional Compensation:• Annual targeted bonus %
Work Location:• On site (San Diego, CA)
