Location: Wilmington, Delaware, USA
Hybrid: 3 days on site

TheUS Senior Medical Director Biologicsprovides US medical leadership for tezepelumab in severe asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, chronic obstructive pulmonary disease, and other disease areas of interest. The role is an integral part of the US Core Medical Team (CMT) and is a primary US medical point of accountability for scientific strategy, evidence generation, and external engagement.

This role is ideally suited for aphysician or pharmacistwith deep expertise in a relevant medical specialty and experience acrosslate-stage development, launch readiness, and post-approval medical excellence. The Senior Medical Director ensures US medical strategy is aligned with global direction while remaining responsive to the healthcare and clinical landscape within the United States.

At AstraZeneca, teams work across global boundaries to make an impact and find answers to complex challenges. This role sits at the heart of that mission, combining scientific depth with strategic leadership to advance care in multiple chronic inflammatory diseases.

Reporting directly to the US Medical Head of tezepelumab, this leader will guide a high-performing team, drive launches, and influence how evidence, access and clinical practice come together to improve outcomes for patients.

Accountabilities:

US Medical Strategy & Asset Leadership:

• Serve as aUS medical leadfor tezepelumab activities, accountable for development and execution of theUS Brand Medical Planacross pre- and post-approval stages.

• Provide strategic medical input to US brand and launch strategy, ensuring alignment of scientific priorities with patient and clinical needs.

• Translate complex biology, clinical data, and disease state insights into actionable US medical strategies.

Medical Responsibilities:

• Lead ongoingpost-approval medical strategyto support appropriate scientific exchange and optimize patient care.

• Drive Phase 4 and lifecycle managementstrategy, including real-world evidence (RWE) and effectiveness studies relevant to US clinicians and payers.

• Provide medical mentorship for US publication strategy and congress planning; medical review of promotional and non-promotional materials.

• US publication management and congress coordination.

• Scientific response strategy and data dissemination.

• Serve as amedical spokespersonfor the US brand as appropriate, supporting external scientific discussions and media inquiries.

• Maintain accountability for the evolvingUS product scientific narrative, incorporating new data, guidelines, and real-world insights.

External Engagement & Scientific Exchange (US-focused):

• Design and implement a comprehensiveUS external engagement plan, including:

  • External Scientific Experts (ESEs)

  • Academic institutions

  • Professional societies

  • Lead planning and participation in national and regional company-led advisory boards

• Ensure high-quality, compliant scientific exchange that advances medical knowledge and education.

Evidence Generation & Medical Governance:

• Collaborate with medical evidence and payer teams to build and implement:

  • Clinical effectiveness studies

  • RWE and health outcomes research

• Provide medical review and governance forExternally Sponsored Research (ESR)proposals.

• Provide medical input intoproduct safety strategyin collaboration with Patient Safety colleagues.

• Ensure compliance with allUS regulatory requirements, FDA standards, PhRMA Code, and AstraZeneca policies.

Internal Collaboration & Capability Building:

• Provide clinical education and scientific training for:

  • US Field Medical organization

  • Cross-functional partners (commercial, market access, HEOR)

• Act as a trusted US medical advisor to internal team members on disease strategy and emerging science.

• Maintain strong collaboration withglobal medical and clinical teams, ensuring seamless alignment while representing US medical needs.

Minimum Requirements:

• Doctoral degree (MD, PhD, MBBS or PharmD)

• 3+ years of demonstrated experience or strong expertise inrespiratory, allergy/immunology, or gastroenterology.

• Experience in late-phase clinical development and/or post-approval medical affairs.

• Well-developed insight into the US regulatory environment, including FDA and OPDP.

• Excellent scientific communication, presentation, and customer engagement skills.

• Ability to travel 25% on average within the US and occasionally internationally.

Preferred Requirements:

• Board certification or eligibility in Internal Medicine, preferably with specialization in pulmonology, immunology and allergy, or digestive system disorders.

• Strong biologics and new product launch experience.

• PriorUS pharmaceutical medical affairs experience, preferably in biologics.

• Experience supportingfirst in class, disease-modifying, or specialty products.

• Strong understanding of theUS payer and provider landscape.

• Shown success in cross-functional leadership and launch execution.

The annual base pay for this position ranges from $243,586.40 - $365,379.60 USD. Annual and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an at-will position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Are you ready to be part of a talented, cross-functional team working together to improve lives and make the biggest possible impact for patients, science and society?

Apply now!