Organization and Position Overview:Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.
In the Project Delivery Phase and Startup Phase of the project (2026 to 2028), roles will be fluid and dynamic as we endeavor to support the project delivery, build a new organization, develop and implement the necessary systems and business processes required to support GMP operations. This will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry goes from design, start-up, and steady-state operations.
The Senior Analytical Scientist role, a technical-track and lab-based position, seeks a collaborative, inclusive, and energetic scientist at the Lilly Medicine Foundry to support the production of synthetic and biologic drug substance processes. This role will collaborate with the parent Chemistry Manufacturing and Control (CMC) development organizations to understand the needs of the portfolio and analytical methods required to deliver on the control strategy of the drug substance. This position will work closely with process engineers, synthetic chemists, process analytical scientists, and production staff, and as such, will require good communication and prioritization skills.
The ASAT group will consist of high-level scientists focused on the implementation of new technologies and analytical process improvements. This position involves working cross-functionally within the site and across the network to identify, develop, and employ new technological solutions to deliver the required information to the project teams. This position will be key to ensuring a strong safety culture and establishing safety, quality, and continuous improvement focused mindset within the organization.
Responsibilities: - Drive implementation of technical solutions and analytical strategies to enable drug substance production at the Lilly Medicine Foundry leveraging traditional off-line testing in the laboratories or in-line/on-line testing via process analytical technology (PAT) on the production floor.
- Transfer analytical methods from Product Research and Development laboratories with an emphasis on communication with other analytical scientists while making improvements on test methods to improve robustness, accuracy, precision and other attributes outlined by ICH guidelines.
- Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple subject areas (chemistry, engineering, analytical sciences, data sciences, etc.).
- Plan and manage short-term and long-term development activities. Develop and/or review technical agendas and timelines for project work. Recommend resource allocation to accomplish projects according to plans, communicate progress and propose changes in timeline, objectives, or direction.
- Collaborate closely with organizations across development and manufacturing to deliver material and information for clinical trials and regulatory submissions for multiple modalities (small molecules, oligonucleotides, peptides, antibodies, antibody conjugates, and other modalities).
- Serve as a subject matter expert (SME) and technical mentor for team members; provide guidance on experimental design, data interpretation, and problem-solving.
- Welcome varied perspectives to create new solutions.
- Coordinate instrumentation between different projects to allow equal usage of available tools for project specific needs.
- Author or contribute to technical documents including SOPs, technology transfer documents, process flow diagrams, regulatory submissions, patents, and scientific papers.
- Present technical findings and project updates clearly and effectively to the ASAT group and other cross-functional teams.
- Ensure work and team activities are aligned with all relevant development quality, regulatory, HSE, GLP and GMP requirements.
Basic Requirements: - B.S. in Chemistry, Analytical Chemistry, Biophysics, Biochemistry, or a closely related STEM field, with at least 8 years of experience in analytical characterization using chromatographic systems coupled with various detectors; or a M.S. with at least 5 years of relevant analytical characterization experience.
- Experience with analytical techniques, including but not limited to HPLC/UPLC, LC-MALS, LC-CAD/ELSD, LC-HRMS, CE/iCE and CE-MS, used for the chemical and/or physical characterization of oligonucleotides, bioconjugates, and biologics modalities.
- Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1
Additional Preferences: - Hands-on experience developing and validating analytical methods for bioconjugates and biologics, including method transfer into GMP manufacturing or QC operations.
- Demonstrated experience supporting pharmaceutical development, with a proven track record of transitioning analytical methods from development into manufacturing and commercial testing environments.
- Demonstrated ability to drive and embrace change in a dynamic environment.
- Good interpersonal skills and a sustained tendency for collaboration.
- Demonstrated success in persuasion, influence, and negotiation.
- Ability to prioritize multiple activities and manage ambiguity.
- Must possess strong communication (oral, written), organizational, and leadership skills.
- Working knowledge of cGMP compliance requirements, with direct cGMP experience.
Other Information:
- Initial location at Lilly Technology Center, Indianapolis or Parkwood West, Indianapolis.
- Permanent location at the new Lilly Medicine Foundry in Lebanon, Indiana.
- Position requires on-site presence, 8-hour days, five days per week, with flexibility to support activities during shutdowns, weekends, overnight operations, etc.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$65,250 - $169,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
