Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biotherapeutics R&D
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:We are searching for the best talent for a
Scientist, Upstream Process Development to be in Spring House, PA.
Purpose:The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processes for in vivo therapeutic programs. This role will contribute to early- through clinical-stage process development, with emphasis on bioreactor execution, media and process optimization, scale-down model generation, and data-driven process understanding for next-generation biologics and genetic medicines.
You will be responsible for:- Design and execute upstream process development studies for lentiviral in vivo therapeutic products under scientific guidance.
- Perform cell culture experiments using shake flasks, bench-scale bioreactors, and automated high-throughput systems.
- Support development of scalable fed-batch and perfusion processes to improve productivity, quality, and manufacturability.
- Utilize Ambr4 250 bioreactor systems for process development, media optimization, and scale-down model studies.
- Apply statistical experimental design, data analytics, and visualization tools to support process understanding and decision-making.
- Build working knowledge of Process Analytical Technology, Raman spectroscopy, online monitoring, and digital bioprocessing tools.
- Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms.
- Support evaluation of novel upstream technologies that improve process robustness and development efficiency.
- Collaborate with downstream, analytical, automation, modeling, and formulation teams to align study design and deliverables.
- Author technical reports, development summaries, protocols, and regulatory-supporting documentation.
Qualifications:
- BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2-4+ years of relevant experience
- Experience in mammalian cell culture process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities.
- Hands-on experience with bioreactor operation, media optimization, process monitoring, and process scale-up support.
- Experience with Ambr4 250 high-throughput bioreactor systems.
- Strong data analysis, experimental design, and technical documentation skills.
- Excellent written and verbal communication skills and ability to work effectively in cross-functional teams.
Required Skills: Preferred Skills:Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Collaboration, Conducting Experiments, Data Quality, Drug Discovery Development, Molecular Diagnostics, Patent Applications, Pharmacogenetics, Report Writing, Research Documents, Scientific Research, Technologically Savvy, Written Expression
