Role Location: Waltham, MA
The RoleWe are seeking a hands-on scientist with strong expertise in LC-MS to lead bioanalytical characterization of oligonucleotide therapeutics, focusing on DMPK and biological interpretation. This LC-MS-focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, protein binding, and structural integrity to answer DMPK-relevant questions and link analytical findings with PK/PD and biological activity.
Key Responsibilities- LC-MS-Driven Bioanalysis: Develop and execute LC-MS/MS and LC-HRMS methods for quantitative and structural analysis of oligonucleotides in biological matrices. Design and perform stability, degradation, and Metabolite Identification (MetID) studies to support DMPK. Provide a higher throughput or automated protein binding data (LC-MS Proteomics) .
- Exposure & Disposition: Apply LC-MS and other methods to assess oligonucleotide-protein interactions, binding, and disposition, interpreting how stability, metabolism, and chemical modifications influence systemic and tissue exposure.
- DMPK & Biological Integration: Interpret LC-MS data within a DMPK context, collaborating with cross-functional teams to link findings with PK, PD, and biological readouts (e.g., target knockdown, gene expression).
- Data Analysis & Communication: Perform quantitative LC-MS data analysis, troubleshoot analytical issues, and clearly communicate analytical and DMPK insights to inform decision-making.
Required Qualifications- Ph.D. or M.S. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field.
- 3+ years (Ph.D) or 10+ years (M.S.) of post-academic experience
- Demonstrated experience with LC-MS and high-resolution MS (HRMS) oligonucleotides bioanalysis, including stability, MetID, and protein binding studies.
- Comfort working cross-functionally in a discovery environment.
Preferred Qualifications- Experience with chemically modified oligonucleotides and/or conjugates.
- Ability to interpret LC-MS data in a DMPK and biological context.
- Exposure to PK/PD concepts and molecular biology-based analytical technologies (e.g., qPCR, ddPCR).
Key Skills & Competencies- LC-MS/MS and LC-HRMS (core expertise)
- Oligonucleotide exposure, stability, metabolism, and protein binding
- DMPK-relevant data interpretation
- Strong troubleshooting ability and scientific judgment
- Clear cross-functional communication
Taking Care of Our PeopleWe support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you're single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
- Competitive base and equity compensation commensurate with level of experience and independence
- 401(k) company match
Health & Family
- Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
- Company-paid disability (STD, LTD) and life insurance
- Paid parental leave
- Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
- Unlimited PTO (paid time off) and flexible schedules
- Annual stipend for continuing education with commitment to your career through individualized professional development plan
- Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Pay TransparencyAt Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $126,000 - $150,000, with the final offer based on factors like your experience, skills, and alignment with our needs.
Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.
We are proud to offer competitive compensation and benefits, aiming to support our team's professional and personal well-being. If you have any questions about pay or benefits, we're here to help.
