Scientist I/II, Antibody Discovery

GondolaBio

$100K — $140K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in Molecular Biology, Biochemistry, or related field with 2+ years of industry experience; M.S. or B.S. with equivalent hands-on experience will be considered.
  • Proficiency in molecular biology techniques such as cloning, PCR, and Gibson assembly.
  • Experience in protein expression and purification from various expression systems.
  • Strong background in antibody screening and developability assays including ELISA and flow cytometry.
  • Experience with immunological assays like ADCP and ADCC, with demonstrated technical skills in cellular biology.

Responsibilities

  • Design and conduct studies essential for antibody discovery and validation, including purification and analysis.
  • Support translational studies focusing on drug candidate mechanisms and biomarker development.
  • Analyze and present experimental data to the research team.
  • Maintain thorough laboratory records, documenting procedures and results.
  • Contribute to writing technical reports and scientific publications.
  • Participate in project planning and design experiments in team meetings.
  • Collaborate and communicate effectively with internal and external team members.

Benefits

  • Patient Days that emphasize understanding patient impacts and exchanging ideas for improvement.
  • A values-driven culture focused on patient-centric research and radical transparency.
  • Collaborative working environment fostering teamwork and innovation.
  • Flexible PTO promoting work-life balance.
  • Opportunities in a fast-paced, data-driven atmosphere with leading research minds.
  • Platforms for making significant scientific contributions.
Full Job Description
Who You Are We are looking for a highly motivated and innovative scientist to join our biologics discovery group at GondolaBio. The selected candidate will work within a fast-paced, interactive, and innovative research team to assist in the development of novel antibodies. This role will require a highly cross-functional skillset, including cell biology, immunology, and protein engineering. Requirements Responsibilities • Design and perform studies critical for antibody discovery and validation, including protein expression, purification, and analysis (e.g., CHO / 293T transfection, Protein A or G purification, SEC / SDS-PAGE / Western blot characterization), binding assays (e.g., ELISA, flow cytometry, SPR, BLI), functional assays (e.g., microscopy, fluorescence reporter assays), and immunological assays (e.g., ADCP, ADCC) • Support translational studies that further elucidate the mechanism and biology for drug candidates, including potential biomarker development • Analyze experimental data and present findings to the team. • Maintain accurate and detailed laboratory records, including experimental procedures, results, and conclusions. • Contribute to the preparation of technical reports, presentations, and scientific publications. • Participate in project meetings and contribute to the design and planning of experiments. • Communicate effectively with team members and external collaborators. • Contribute to due diligence and gap analysis on potential new GondolaBio assets Education, Experience & Skills Requirements • Ph.D. in Molecular Biology, Biochemistry, or related discipline with 2+ years hands-on industry experience. M.S. and B.S. candidates with equivalent experience will also be considered. Knowledge, Skills, and Abilities • Proficiency in molecular biology techniques (e.g., cloning, PCR, Gibson assembly, Golden Gate) • Proficiency in protein expression and purification methods (e.g., mammalian, insect, and bacterial expression systems). • Experience with antibody screening and developability assays (e.g., ELISA, flow cytometry, SPR, BLI, developability assessments • Experience working with cell lines in tissue cultures, running western blots and cell-based assays. • Experience with downstream immunological assays (e.g., ADCP, ADCC, CDC, multicolor flow cytometry) • Strong problem-solving skills, attention to detail, and teamwork. • Ability to work in a fast-paced environment • Strong scientific background and achievements in bioscience and translational medicine, ideally demonstrated by scientific publications, presentations, and/or patents • Proven track record of successfully working in research programs • Strong understanding of drug discovery and development processes • Excellent communication (written & verbal) and organizational skills • Ability to think strategically and execute experiments effectively • Experience in collaborating with cross-functional teams and external partners • Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals • Commitment, drive, and ownership mindset What We Offer: • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts • A culture inspired by our values: put patients first; think independently; be radically transparent; every minute counts; and let the science speak • Collaborative business environment • Excellent compensation package (Base, Performance Bonus, Equity) • Excellent benefits package • Flexible PTO • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities • Work with the most productive groups of R&D operators in the industry • A platform for meaningful scientific contributions to shine The base pay range for this position is $100,000 to $140,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.

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