Scientist I, Discovery & Translational Development - Solid Biosciences Charlestown, MAWe are seeking a highly motivated and scientifically rigorous Scientist I to join our Discovery and Translational Development team. This individual will contribute to the advancement of innovative genomic medicine programs for rare cardiomyopathies and neuromuscular diseases, spanning both preclinical and clinical-stage programs.
This is an exciting opportunity for a driven scientist who wants to work at the intersection of discovery biology, translational science, and clinical development. The successful candidate will report to a Scientific Lead and will play an important role in generating, interpreting, and communicating data that helps move programs from concept through clinical execution.
We are looking for someone who understands the promise and complexity of gene therapy and genomic medicines, can think critically in real time, and is energized by solving hard scientific problems in a fast-moving environment. This is an on-site position based out of our HQ in Charlestown, MA.
Key Responsibilities- Support the scientific execution of preclinical and clinical-stage programs in rare neuromuscular and cardiovascular diseases.
- Design, coordinate, and interpret studies that inform program strategy, candidate selection, mechanism of action, translational biomarkers, dose selection, and clinical development.
- Work closely with Scientific Leads to advance program priorities, identify key scientific questions, and develop data-driven recommendations.
- Collaborate cross-functionally with platform, research, clinical, regulatory, bioanalytical, CMC, pharmacology, toxicology, and program management teams.
- Analyze and synthesize complex datasets across in vitro, in vivo, translational, and clinical studies.
- Contribute to experimental strategy for AAV gene therapy and other genomic medicine approaches, including vector biology, tissue targeting, expression, efficacy, safety, immunology, and translational relevance.
- Help identify and resolve scientific and technical challenges that arise during program execution.
- Prepare high-quality scientific summaries, presentations, study reports, and decision-making materials for internal governance forums.
- Engage with external collaborators, CROs, academic investigators, and scientific advisors as needed.
- Stay current with advances in gene therapy, genomic medicines, rare disease biology, translational biomarkers, and competitive programs.
- Operate with scientific curiosity, urgency, accountability, and a strong commitment to developing meaningful therapies for patients.
Qualifications- PhD in molecular biology, genetics, cell biology, pharmacology, neuroscience, cardiovascular biology, muscle biology, or a related discipline and 0-2+ years of relevant postdoctoral, industry, or translational research experience preferred; or equivalent experience in biotechnology, pharmaceutical, or translational research settings.
- Experience with gene therapy, AAV biology, genomic medicines, RNA-based therapeutics, genetic disease, or related therapeutic platforms strongly preferred.
- Strong understanding of preclinical study design, translational biology, and the use of disease models to support therapeutic development.
- Experience in neuromuscular disease, cardiomyopathy, rare disease, or genetic medicine is highly desirable.
- Ability to critically evaluate complex scientific data and translate findings into clear recommendations.
- Strong written and verbal communication skills, with the ability to present scientific concepts clearly to technical and cross-functional audiences.
- Demonstrated ability to work collaboratively in a matrixed, fast-paced environment.
- High level of ownership, intellectual curiosity, adaptability, and scientific judgment.
- Comfortable navigating ambiguity and contributing to decisions when data are evolving or incomplete.
Preferred Experience- Experience supporting programs from discovery through IND-enabling studies or early clinical development.
- Familiarity with translational biomarkers, biodistribution, pharmacology, toxicology, immunogenicity, and clinical assay strategies.
- Experience working with CROs, academic collaborators, or external scientific partners.
- Familiarity with regulatory-enabling datasets for genetic medicine programs.
- Experience preparing scientific materials for internal governance, regulatory interactions, investor-facing materials, or external scientific presentations.
Core Competencies- Scientific rigor and critical thinking
- Strong problem-solving skills and ability to think quickly
- Data-driven decision-making
- Clear and concise communication
- Cross-functional collaboration
- Ownership and accountability
- Adaptability in a fast-moving environment
- Passion for rare disease and patient impact
Compensation The base compensation range for this role is: $125,000.00 - 140,000.00
Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid's long term company performance.
Benefits and Solid Advantages At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees' lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.
- Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
- 401(k) program participation with competitive company matched contributions
- Eligibility to participate in Solid's Employee Stock Purchase Plan
- Mobile phone subsidy for eligible employees
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- Employee Discount Program on Travel, Entertainment, and Services
- Employee Assistance Programs
- Daily Subsidized Lunch Delivery (onsite @ Hood Park)
- Free Onsite Full-Service Gym (onsite @ Hood Park)
- Employee Parking (onsite @ Hood Park)
- 12 Observed Holidays and a winter shut down
- 15-day PTO Policy and an 80-hour rollover YoY
