Abzena plc

Process Chemist III

Abzena plc$95K — $115K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in Organic Chemistry with 2+ years of industry experience, or M.S. with 5+ years of industry experience.
  • Strong knowledge of synthetic organic chemistry and process development.
  • Proficient in reaction optimization, impurity control, and process scale-up.
  • Familiar with analytical techniques like UPLC, HPLC, LC-MS, GC, and NMR.
  • Excellent scientific writing, communication, and presentation skills.
  • Proven ability to manage multiple projects in fast-paced environments.

Responsibilities

  • Design and optimize synthetic routes for small molecules and drug-linker compounds.
  • Develop scalable and cost-effective manufacturing processes for cGMP production.
  • Conduct laboratory experiments and analyze data for process improvement.
  • Troubleshoot scale-up and synthetic issues using scientific principles.
  • Collaborate with cross-functional teams for technology transfer and manufacturing.
  • Document technical reports and maintain compliance with regulations.
  • Mentor junior scientists on experimental design and process development.
  • Present technical data and project updates in client meetings.
  • Engage in continuous improvement initiatives for safety, quality, and efficiency.

Benefits

  • Supportive team environment focused on collaboration and professional development.
  • Opportunities for mentorship and technical guidance.
  • Involvement in cutting-edge projects within the pharmaceutical and biotechnology sectors.
  • Commitment to safety, quality, and sustainability in processes.
Full Job Description
We are seeking a highly motivated Process Chemist III to join our Process Development team. The successful candidate will lead the development, optimization, and scale-up of synthetic processes for small molecules, linker-payloads, intermediates, and related compounds from early development through cGMP manufacturing. This role requires strong technical expertise, excellent problem-solving skills, and the ability to collaborate effectively with cross-functional teams.

Responsibilities
• Design, execute, and optimize synthetic routes for small molecules, intermediates, and complex drug-linker compounds.
• Develop scalable, robust, and cost-effective manufacturing processes suitable for pilot plant and cGMP production.
• Plan and perform laboratory experiments, analyze data, and interpret results to guide process improvements.
• Troubleshoot challenging synthetic and scale-up issues using sound scientific principles.
• Collaborate with Analytical Development, Manufacturing, MSAT, Quality, Supply Chain, and Project Management teams to ensure successful technology transfer and manufacturing campaigns.
• Prepare technical reports, batch records, process descriptions, risk assessments, and technology transfer documentation.
• Maintain accurate laboratory notebooks and ensure documentation complies with company and regulatory standards.
• Mentor junior scientists and provide technical guidance on experimental design and process development.
• Support client meetings by presenting technical data and project updates.
• Contribute to continuous improvement initiatives focused on safety, quality, efficiency, and sustainability

Qualifications
• Ph.D. in Organic Chemistry with 2+ years of industrial experience, or
• M.S. in Organic Chemistry with 5+ years of industrial experience, or
• Strong knowledge of synthetic organic chemistry and process development.
• Experience with reaction optimization, impurity control, and process scale-up.
• Experience with analytical techniques such as UPLC, HPLC, LC-MS, GC, and NMR.
• Excellent scientific writing, communication, and presentation skills.
• Demonstrated ability to manage multiple projects in a fast-paced environment.

Preferred
• Experience in pharmaceutical, biotechnology, or CDMO environments.
• Experience supporting cGMP manufacturing campaigns and technology transfer.
• Experience with linker-payload synthesis, peptide coupling chemistry, or highly potent compounds is desirable.

Physical Requirements
• Ability to stand for 1-2 hours at a time, sit for 2 to 3 hours at a time.
• Frequently lift and or move objects up to 30 pounds.
• Stand/walk during entire length of shift.
• Use arms, hands, and fingers to handle, feel or reach.
• Ability to climb, balance, stoop, kneel, crouch, or crawl.
• Visual abilities including near and far sight, color, peripheral vision, depth, and ability to focus.
• Ability to work with a PAPR and gown during work with high potent materials.

FLSA: Exempt

About Abzena plc

Abzena is a life sciences group with headquarters in Cambridge, UK and offices in the US and Japan. The company provides technologies and complementary services to enable the development and manufacture of biopharmaceutical products. Abzena's services and technologies are used by a range of companies and academic organisations across the pharmaceutical industry, including small biotech to large pharmaceutical companies. The company's proprietary technologies include composite human antibodies and site-specific conjugation technologies, which enable the development of antibody drug conjugates (ADCs) and other biotherapeutics. Abzena's services include antibody discovery and engineering, immunology services, bioassays, cell line development, and biomanufacturing. The company has a range of partnerships and collaborations with pharmaceutical companies and academic institutions, and has a number of products in clinical development.
Learn more about Abzena plc
Size
200 employees
Industry
Founded
2014
Revenue
$17 million
NASDAQ

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