We are seeking a Precision Medicine Strategy Lead (PMSL) at the Principal Scientist level responsible for the clinical biomarker strategy for multiple clinical stage assets in Regeneron's Immunology & Inflammation (I&I), Ophthalmology and Infectious Diseases portfolios.
The successful candidate will be motivated and innovative in their proposals for clinical biomarker strategies that drive the success of both early and late-stage clinical programs. They will be knowledgeable regarding key literature and relevant technologies. They will thrive in a collaborative environment and regularly partner with research teams, clinical development, laboratory operations, companion diagnostics, clinical operations, tech centers, alliance partners, external academic collaborators, and others. They will be exceptional communicators as they routinely present their strategy, rationale and data to senior leaders.
This is a high-impact, highly visible role at the intersection of science and strategy in Regeneron’s Translational Medicine organization. The work done as a Principal Scientist will enable endpoint selection, choice of clinical indication, and demonstration of target engagement, early signs of activity, mechanism of action and patient stratification/selection.
As a Lead, a typical day may include:
Define and champion the strategic vision and scientific rationale for clinical biomarker plans supporting one or more programs in I&I, Ophthalmology, and/or Infectious Disease
Serve as a Precision Medicine representative on clinical development teams, driving biomarker strategy from initial concept through execution, data delivery, and interpretation.
Partner with clinical and laboratory operations to implement biomarker and exploratory sample collection and analyses
Ensure clinical biomarker assays are fit-for-purpose — whether developed internally or through external collaborators/CROs
Present translational project plans, biomarker data, and results to internal and external stakeholders, including senior leadership
Contribute to the highest-quality Precision Medicine content in clinical protocols, study reports, data reviews, biomarker reports and manuscripts/publications
This role might be for you if can:
Translate complex immunology and disease biology into clear, testable clinical biomarker hypotheses and decision criteria.
Lead cross-functional teams to design, operationalize, and troubleshoot end-to-end biomarker plans across global studies.
Drive fit-for-purpose assay development and validation with internal labs and CROs, balancing scientific rigor, cost, and timelines.
Synthesize and communicate biomarker insights into compelling narratives for diverse stakeholders, including senior leadership, to inform key decisions.
Navigate ambiguity, prioritize across multiple programs, and foster a collaborative, innovative culture in a matrixed environment.
To be considered for this role, you must have:
Ph.D. with post-doctoral experience in Immunology or closely related field is highly desirable
5+ years of relevant experience in pharmaceutical/biotech industry research and/or translational clinical development
Exceptional communicator with strong emotional intelligence and enthusiasm for presenting to senior leaders
Collaborative, innovative, and energized by working in a matrixed environment
Understanding of biomarker strategy in clinical development, including assay development, validation, and implementation with a track record of high-impact contributions to drug development programs is a huge plus
Experience authoring industry documents (protocols, CSRs, biomarker reports) is a plus
Alternative levels will be considered commensurate with experience
$128,600.00 - $210,000.00
