Eli Lilly

MES Technical Lead / Systems Architect LP2

Eli Lilly$129K — $211K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in IT, Software/Computer Engineering or related field
  • 5+ years of experience with MES in pharma manufacturing IT platforms
  • Experience in system integration with middleware/ERP/PLM and Computer System Validation (CSV)
  • Familiarity with modern software architecture and integration patterns
  • Understanding of regulatory requirements such as 21 CFR Part 11/ALCOA+

Responsibilities

  • Lead the technical direction of LP2 MES architecture and design
  • Design and validate Tulip applications for manufacturing workflows
  • Direct automation integrations with Engineering for process control
  • Author and approve design specifications for compliance
  • Guide components through the validated migration lifecycle
  • Participate in change management processes through CCB
  • Mentor MES engineers and act as a point of escalation for complex issues

Benefits

  • 401(k) and pension plans
  • Medical, dental, vision, and prescription drug benefits
  • Flexible spending accounts for healthcare and dependent care
  • Life insurance and death benefits
  • Well-being benefits including employee assistance programs and fitness benefits
Full Job Description
LP2 MES Technical Lead & Systems Architect - Lebanon, Indiana

Lilly is building a new gene therapy manufacturing site (LP2) in Lebanon, Indiana. This role owns the Manufacturing Execution System (MES) end-to-end - from the Tulip application layer and Tulip Table data model, through MuleSoft integrations connecting SAP, QbDVision, and LabVantage, to the MQTT-based Unified Namespace driving real-time equipment communication. You will serve as both the technical authority over the platform's architecture and the hands-on engineer responsible for its ongoing design, build, and validation.

Key Responsibilities

  • Serve as Technical Lead/SME for LP2 MES architecture, design standards, and technical direction


  • Design, build, and validate Tulip applications for GxP manufacturing workflows and electronic batch records


  • Direct automation integrations with Automation Engineering (equipment commands, confirmations, process value subscriptions)


  • Author/approve design specs ensuring compliance with ALCOA+ and 21 CFR Part 11


  • Guide components through validated migration lifecycle (DEV 12 QA 12 Production)


  • Participate in Change Control Board (CCB) and ServiceNow change management


  • Partner with Manufacturing Operations, Automation Engineering, and Quality (BQA/CSQA)


  • Mentor MES engineers; act as escalation point for complex issues


  • Collaborate with MES Product Owner on ALM requirements/backlog


  • Report system status and technical risk to site/IT leadership


Basic Requirements

  • Bachelor's degree in IT, Software/Computer Engineering or related field


  • 5+ years with MES or pharma manufacturing IT platforms, including system integration (middleware/ERP/PLM) and Computer System Validation (CSV) in GMP settings


  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.


Additional Skills/Preferences

  • Modern software architecture and integration patterns


  • MuleSoft/Anypoint, DataWeave for MES-ERP(SAP)-PLM integrations


  • MQTT, Unified Namespace (UNS), OPC UA knowledge


  • CSV experience: Validation/Test Plans, IQ/OQ/UAT, design specs under 21 CFR Part 11/ALCOA+


  • Understanding of eBRs, non-terminal record controls, e-signatures


  • Git/GitHub, GitHub Actions, MUnit, ALM/Jira


  • Familiarity with MABL and ServiceNow


  • Strong cross-functional communication and problem-solving skills


Additional Information:

  • Position Location: Lebanon, Indiana, with potential travel to other U.S. and global Lilly sites as required.


  • Travel Percentage (%):


  • Shift Information: Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate production schedules, batch execution windows, and change control activities. Occasional extended hours and/or off-hour support may be required.


Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$129,000 - $211,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ

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