Twist Bioscience

Manager, Site Reliability Engineer

Twist Bioscience • $210K — $243K *
Information Technology
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • 5-7+ years of experience in Site Operations or similar roles
  • Proven leadership or mentoring experience with engineering or operations teams
  • Hands-on expertise with cloud platforms like AWS, Azure, or GCP
  • Proficient in managing Kubernetes environments in production
  • Strong grasp of networking concepts (DNS, load balancing, firewalls)
  • Experience with observability tools such as Splunk
  • Scripting knowledge in Python, Bash, or Terraform

Responsibilities

  • Lead the Site Operations / SRE function
  • Own cloud infrastructure architecture and scalability
  • Ensure production applications' high availability and reliability
  • Drive operational excellence through automation and monitoring
  • Maintain observability platforms for logging, metrics, and tracing
  • Oversee Kubernetes-based infrastructure and container orchestration
  • Collaborate to enhance deployment processes and system resilience
  • Implement infrastructure security and compliance best practices

Benefits

  • Bonus eligibility
  • Equity offerings
  • Generous benefits package
  • Hybrid work model
  • Opportunities for professional development
Full Job Description
Manager, Site Reliability Engineer (Hybrid in South San Francisco)
About the Role

We are seeking an experienced and hands-on Site Reliability Engineering (SRE) Manager to lead our Site Operations and infrastructure initiatives. This role is responsible for ensuring the reliability, scalability, security, and performance of our cloud infrastructure and critical applications.

The ideal candidate combines strong technical expertise with leadership experience and a passion for operational excellence. You will lead efforts across cloud infrastructure, observability, automation, networking, and platform reliability while partnering closely with engineering and product teams to support business-critical applications.
Responsibilities
  • Lead and manage the Site Operations / SRE function
  • Own cloud infrastructure architecture, operations, scalability, and optimization
  • Ensure high availability and reliability of production applications and services
  • Drive operational excellence through automation, monitoring, and incident management
  • Develop and maintain observability platforms including logging, metrics, alerting, and tracing
  • Manage Kubernetes-based infrastructure and container orchestration environments
  • Oversee networking, DNS, CDN, and storage infrastructure across cloud environments
  • Collaborate with software engineering teams to improve deployment processes, system resilience, and performance
  • Establish and improve CI/CD pipelines and infrastructure-as-code practices
  • Lead incident response, root cause analysis, and post-incident remediation efforts
  • Manage vendor and platform relationships where applicable
  • Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement
  • Define and implement infrastructure security and compliance best practices
Required Qualifications
  • 5-7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles
  • Prior experience leading or mentoring engineering or operations teams
  • Strong hands-on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP)
  • Experience managing Kubernetes (K8s) environments in production
  • Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies
  • Experience with Akamai CDN administration and optimization
  • Experience with observability and monitoring platforms, including Splunk
  • Experience with storage infrastructure and cloud-native storage solutions
  • Strong scripting and automation experience (Python, Bash, Terraform, or similar)
  • Experience implementing and maintaining CI/CD pipelines
  • Strong troubleshooting and incident management skills in complex distributed systems
  • Excellent communication and cross-functional collaboration skills
Preferred Qualifications
  • Experience managing hybrid or multi-cloud environments
  • Experience with infrastructure-as-code and GitOps methodologies
  • Familiarity with security best practices and compliance frameworks
  • Experience supporting highly available enterprise or SaaS platforms
  • Strong understanding of container security and cloud-native architectures


The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$210,383-$243,210 USD

About Twist Bioscience

Twist Bioscience Corporation is a biotechnology company that develops and produces synthetic DNA and RNA. The company's platform allows for the rapid and cost-effective production of custom DNA and RNA sequences, which can be used in a variety of applications such as drug discovery, diagnostics, and data storage. Twist Bioscience's customers include academic and research institutions, pharmaceutical and biotechnology companies, and government agencies. The company was founded in 2013 and is headquartered in San Francisco, California.
Learn more about Twist Bioscience
Size
652 employees
Market Cap
$1.2 billion
Industry
Net Income
-$117.1 million
Founded
2013
5 Year Trend
+80%
Revenue
$101.1 million
NASDAQ

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