Reporting to the Director of Feasibility, the Feasibility Principal provides strategic, study-level feasibility leadership within the Patient and Site Engagement (PSE) team, supporting the acceleration of clinical studies across rare disease programs. This role leads feasibility strategy and analysis for assigned studies, translating complex operational and enrollment data into clear, data-driven recommendations that inform study planning and enrollment decisions. Working cross-functionally, the Feasibility Principal also contributes to continuous improvement efforts and mentors junior team members, while operating effectively in a fast-paced, dynamic environment.

What You Will Be Doing:

• Working closely with, and under the strategic guidance of, the PSE Director or Associate Director, the Feasibility Principal leads feasibility activities for assigned clinical studies.

• Lead feasibility strategy and execution at the study level, supporting trial optimization and delivery of key milestones, while ensuring alignment with broader program objectives and feasibility standards.

• Synthesize and analyze feasibility, operational, and enrollment data from multiple internal and external sources to develop a comprehensive understanding of therapeutic areas, standard of care, disease progression, patient and site profiles, and the competitive landscape.

• Evaluate the clinical trial landscape and apply advanced data mining and analytical approaches, including complex enrollment modeling and forecasting, to translate findings into data-driven enrollment assumptions, risk assessments, and strategic recommendations.

• Operate effectively in a fast-paced, dynamic study environment, rapidly assessing changing inputs, reprioritizing work, and adjusting feasibility approaches to meet tight timelines.

• Apply strong time management and prioritization skills to balance multiple studies and last-minute requests while maintaining analytical rigor and clear communication.

• Serve as a key feasibility partner with cross-functional study teams, clearly communicating insights, assumptions, risks, and recommendations to support study planning, site selection, and enrollment strategy decisions.

• Lead and deliver data-driven presentations to cross-functional teams and governance forums, including presenting analyses and responding to questions from senior leadership, as appropriate.

• Mentor and provide guidance to junior feasibility team members, supporting development of analytical skills, best practices, and consistency in deliverables.

• Apply strong operational judgment and clinical trial expertise to proactively identify challenges, anticipate risks, and drive solutions.

• Contribute to continuous improvement of feasibility processes, tools, and best practices by sharing insights and lessons learned.

Your Profile:

• Bachelor’s degree in a scientific or allied health field (or equivalent industry experience), with 7+ years of progressive experience in clinical research, feasibility, clinical operations, or study startup within a sponsor or CRO environment.

• Minimum of 5 years of hands-on operational feasibility experience supporting complex studies or programs.

• Demonstrated experience leading feasibility strategy for complex studies or programs, with a proven track record of influencing decisions related to site selection, enrollment strategy, and study acceleration.

• Experience working across multiple therapeutic areas or late-phase programs with increasing strategic accountability.

• Demonstrated ability to analyze, synthesize, and interpret complex feasibility, operational, and enrollment data, translating findings into clear insights and actionable recommendations.

• Advanced proficiency in Excel and other data-driven analysis tools, including experience in structuring, analyzing, and presenting data for feasibility assessments, benchmarking, and enrollment forecasting.

• Strong verbal and written communication skills, with the ability to clearly present complex, data-driven analyses to diverse stakeholders.

• Demonstrated critical thinking and solution-oriented, creative problem-solving skills.

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits may include:

• Competitive base salary and performance related incentives
• Health and wellbeing programmes including medical, dental, and vision coverage where applicable
• Retirement and pension plans
• Life assurance and disability coverage
• Employee assistance programmes and wellbeing resources
• Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

Visit our to read more about the benefits ICON offers.