Kymera Therapeutics

Endpoint Systems Engineer

Kymera Therapeutics$115K — $200K *
Information Technology
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • 5+ years supporting Windows endpoints in an enterprise setting
  • Experience deploying apps and managing policies via Microsoft Intune
  • Proficient in troubleshooting OS, identity, and Microsoft 365 services
  • Skilled in PowerShell scripting for automation
  • Familiar with hybrid Entra ID/Azure AD identity frameworks
  • Experience in diagnosing hardware issues and coordinating repairs
  • Strong communication skills, both written and verbal

Responsibilities

  • Serve as L3 escalation for endpoint and user support within a hybrid Microsoft environment
  • Package and maintain Win32 applications using Microsoft Intune
  • Troubleshoot hybrid identity issues and support user identity processes
  • Provide advanced troubleshooting for Microsoft 365 services like Exchange and Teams
  • Diagnose and resolve Windows client issues using advanced tools
  • Develop and maintain PowerShell scripts for remediation and automation
  • Collaborate with cybersecurity team on endpoint security alerts

Benefits

  • Competitive compensation package
  • Eligibility for annual bonus
  • Equity participation
  • Comprehensive benefits package
Full Job Description


How you'll make an impact:

Kymera Therapeutics is seeking a highly capable Desktop Engineer to serve as the L3 escalation point for endpoint and user support within our hybrid Microsoft environment. This role is central to maintaining a secure, reliable, and well-managed computing experience for employees across the organization. The engineer will handle advanced troubleshooting, modern device management with Intune, identity and authentication support, and deep Windows client diagnostics.

The ideal candidate brings a cloud-first mindset, with the judgment and experience to operate effectively in an environment where cloud and on-premises systems still coexist. They should understand the realities and constraints of a hybrid infrastructure while actively helping the organization move toward more modern, cloud-aligned practices. This role requires strong technical instincts, the ability to collaborate across Infrastructure, Cybersecurity, and Applications teams, and a commitment to improving the stability, security, and effectiveness of the end-user computing environment.

Endpoint Management & Intune Support
  • Package, deploy, and maintain Win32 applications through Microsoft Intune
  • Build and update remediation scripts, configuration profiles, and compliance policies
  • Troubleshoot Autopilot enrollments, ESP issues, and device identity inconsistencies
  • Ensure consistent device hygiene, lifecycle management, and operational readiness

Identity & Access Management
  • Troubleshoot hybrid identity issues involving Entra ID, Azure AD Connect, and device join states
  • Support user and device identity lifecycle processes
  • Resolve authentication failures, directory sync issues, and group-based access concerns
  • Contribute to identity-related troubleshooting improvements and best practices

Microsoft 365 Support & Escalation
  • Provide advanced troubleshooting for Exchange Online, Teams, SharePoint, and OneDrive
  • Diagnose and resolve mail flow problems, permission conflicts, and policy inconsistencies
  • Support configuration and lifecycle management of M365 Groups
  • Assist with cross-service issues affecting collaboration and user productivity

Windows Client Engineering
  • Diagnose OS, driver, performance, profile, and Windows Update issues using advanced tools
  • Analyze event logs and system telemetry to determine root causes
  • Identify recurring endpoint issues and recommend corrective actions
  • Support imaging and Autopilot health by addressing underlying system issues

Scripting & Automation
  • Develop and maintain PowerShell scripts for support, remediation, and automation
  • Use JSON and basic Graph API calls when necessary
  • Identify opportunities to reduce manual work and improve consistency

Security & Compliance Support
  • Apply endpoint hardening practices and configuration standards
  • Perform initial triage of endpoint security alerts before escalation
  • Work closely with the Cybersecurity team on incident workflows and risk mitigation
  • Maintain device and user compliance with organizational policies

Networking & Connectivity Support
  • Troubleshoot DNS, VPN clients, Wi-Fi issues, and routing-related symptoms
  • Determine whether issues originate from the endpoint or the broader network
  • Assist users with connectivity problems affecting productivity

Hardware Diagnostics & Warranty Coordination
  • Use OEM diagnostic tools to identify potential hardware faults
  • Distinguish hardware failures from software or configuration issues
  • Coordinate RMAs, warranty service requests, and device replacements
  • Validate device health and readiness following repair or replacement

Cross-Team Collaboration & Documentation
  • Act as an escalation point for L1 and L2 support teams
  • Document troubleshooting procedures, runbooks, and best practices
  • Collaborate with Infrastructure, Cybersecurity, and Applications teams
  • Contribute to continuous improvement of endpoint-related processes


Skills and experience you'll bring:
  • 5+ years supporting Windows endpoints in an enterprise environment
  • Experience with Microsoft Intune app deployment, policy management, and device troubleshooting
  • Strong troubleshooting skills across OS, identity, and Microsoft 365 services
  • PowerShell scripting skills for automation and remediation workflows
  • Solid understanding of hybrid Entra ID / Azure AD identity concepts
  • Experience diagnosing hardware issues and coordinating warranty repairs
  • Familiarity with DNS, VPN, and Wi-Fi troubleshooting
  • Strong written and verbal communication skills

Preferred Qualifications
  • Experience with Defender for Endpoint
  • Background in hybrid AD DS + Entra ID environments
  • Exposure to regulated industry environments (biotech, pharma, etc.)
  • Experience supporting modern endpoint and collaboration ecosystems

Personal Attributes
  • Analytical, detail-oriented, and methodical approach to problem-solving
  • Strong ownership mentality and follow-through on escalated issues
  • Comfortable collaborating across technical and non-technical teams
  • Committed to delivering a high-quality end-user computing experience


Compensation
  • Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
  • The anticipated base salary range for this role is $115,000 - $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
  • Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate's depth of experience and the capabilities they bring to the position.

About Kymera Therapeutics

Kymera Therapeutics is a clinical-stage biopharmaceutical company that is focused on discovering and developing novel small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. The company's proprietary targeted protein degradation platform, Pegasus, is designed to harness the body's natural protein recycling machinery to degrade disease-causing proteins, with a focus on undruggable and difficult-to-drug targets. Kymera's initial programs are focused on oncology and immunology, with a goal of delivering transformative therapies for patients with previously untreatable diseases. Kymera was founded in 2015 and is headquartered in Cambridge, MA.
Learn more about Kymera Therapeutics
Size
75 employees
Market Cap
$1.4 billion
Industry
Founded
2017
NASDAQ

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