Key Responsibilities:

• We are seeking a highly motivated contractor with a passion for using high-dimensional single cell immune profiling data in conjunction with innovative computational approaches and systems immunology knowledge to transforming vaccine research.
• Responsibilities will be developing analytical tools used for bulk RNAseq, single cell RNAseq, TCR sequencing, BCR sequencing, and host immune profiling.
• This role will integrate multi-omics data with preclinical/clinical data and provide scientific insights to immune responses elicited by vaccines or pathogens.
• Will collaborate in a cross-functional teams and make strong impact to all stages of vaccine R&D.
• Integrate and analyze multi-omics datasets (e.g., transcriptomics, proteomics, metabolomics) to identify biomarkers and molecular signatures relevant to vaccine efficacy and safety.
• Leverage public omics databases (e.g., GEO, ENCODE, UK Biobank, CELL×GENE) to support hypothesis generation and validation.
• Provides scientific insights to innate and adaptive immune responses induced by vaccines.
• Ability to handle single-cell data from raw data acquisition to data visualization and data analysis.
• Develop, document, and maintain reproducible computational pipelines and scripts using R and Python.
• Communicate complex data and results clearly to both technical and non-technical stakeholders.
• Collaborate extensively with those from other scientific disciplines from within the group, from other subdivisions of Vaccines R&D, from other divisions and potentially from external partners.

Required Qualifications:

• Ph.D. in a relevant scientific field with a strong background in computational biology or bioinformatics w/ 1-3 yrs exp
• Extensive experience in analyzing multi-omics data (e.g., genetics, bulk RNA-seq, single-cell RNA-seq, spatial omics, proteomics, etc.) for biomedical research.
• Experience in biomarker discovery, particularly in the context of vaccine or immunology research.
• Familiarity with public omics databases and data repositories.
• Familiar with Linux environments, high-performance computing and/or cloud computing environment and broad experience with open-source bioinformatics tools to generate immunological insight.
• Strong communication and collaboration skills with the ability to work effectively in a hybrid team environment.
• Familiar with state-of-art technology related to bulk RNAseq, single cell RNAseq, TCR profiling, and BCR profiling.
• Skill: 10X Single Cell, BCR TCR, Bioinformatics, Computational biology, data science, Next Generation Sequencing (NGS), transcriptomics, immunology, Vaccines, proteomics, and Genomics.

Preferred Qualifications:

• Extensive hand-on experience generating immunological insight from single cell sequencing data is highly desirable.
• Knowledge of machine learning techniques applied to biological data.
• Familiarity with artificial intelligence-empowered multimodal foundation models such as scGPT, UCE, scFoundation, Mal-ID
• Strong organizational skills and attention to detail in managing multiple projects and deadlines.
• Ability to document code thoroughly to ensure reproducibility and clarity for collaborative projects.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance : Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.