Job Family:Research Scientists (SCI)
Travel Required:None
Clearance Required:Ability to Obtain Public Trust
What You Will Do:We are looking for a Biologist to support drug repurposing screening projects, disease model development, assay development, and scientific research activities for the National Center for Advancing Translational Sciences (NCATS). This is a full-time position located in Rockville, MD.
- Work with assay providers for assay development and assay transfer to the TDB program.
- Perform assay development, optimization, and miniaturization activities.
- Conduct high throughput screening using known drugs and bioactive compounds to identify active compounds.
- Confirm primary hits and perform secondary and tertiary assays to narrow candidates to top lead compounds.
- Perform mechanistic studies to characterize lead compounds when necessary.
- Evaluate and apply new technologies and instruments to establish physiologically relevant disease models.
- Characterize human induced pluripotent stem cells (iPSCs) and iPSC-derived cells, including developmental marker analysis and disease phenotype studies.
- Establish human iPSC-derived cell-based assays for disease modeling.
- Lead assay development and compound screening using high-content imaging and flow cytometry assays.
- Operate and maintain high throughput flow cytometry instrumentation, including the iQue flow cytometer.
- Maintain accurate scientific records and communicate effectively with collaborators and project teams.
- Present research findings at internal and external scientific meetings.
- Write, submit, and support the publication of scientific manuscripts.
- Assist team members with manuscript preparation and revisions.
- Collaborate with staff scientists, postdoctoral fellows, IRTA fellows, and external collaborators.
- Mentor and train postbaccalaureate IRTA fellows and summer students.
- Support the overall operational and scientific objectives of NCATS research programs.
- Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer
What You Will Need:- Ph.D. in Molecular, Cell Biology, or Biological Sciences.
- Minimum of EIGHT (8) years of experience in flow cytometry assays.
- Experience in assay development, high-content imaging assay analysis, compound screening, and lead identification.
- Experience with in vitro and in vivo disease model systems.
- Proficiency with FlowJo, GraphPad Prism, and Microsoft Office.
- Strong oral and written communication skills.
- Demonstrated ability to write scientific manuscripts and present scientific data and research findings.
- Ability to maintain accurate laboratory documentation and records.
- Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.
What Would Be Nice To Have:- Background supporting drug repurposing programs.
- Ability to work independently and collaboratively in a multidisciplinary research environment.
- Hands-on use of high throughput screening platforms and technologies.
- Ability to establish disease models using human primary cells or iPSC-derived cells.
- Skilled in mentoring junior researchers, fellows, and students.
- Collaborative approach with external scientific partners and multidisciplinary project teams.
- Scientific publication record in peer-reviewed journals.
- Track record presenting research at national or international scientific conferences.
The annual salary range for this position is $115,200.00-$172,800.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.
What We Offer:Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
- Medical, Rx, Dental & Vision Insurance
- Personal and Family Sick Time & Company Paid Holidays
- Parental Leave
- 401(k) Retirement Plan
- Group Term Life and Travel Assistance
- Voluntary Life and AD&D Insurance
- Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
- Transit and Parking Commuter Benefits
- Short-Term & Long-Term Disability
- Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
- Employee Referral Program
- Corporate Sponsored Events & Community Outreach
- Care.com annual membership
- Employee Assistance Program
- Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
- Position may be eligible for a discretionary variable incentive bonus
