Neomorph is seeking an experienced associate scientist with a passion for drug discovery and extensive experience with BSL2/2+ practices and routine molecular and cell biology techniques. The role will be critically involved in supporting Neomorph's internal pipeline through contributions to both target identification and validation efforts, as well as by enabling decision-making through the generation of robust data packages. The successful applicant will be an integral member of project teams and will be responsible for communicating broadly across the organization.
Key ResponsibilitiesProfile the biological activities of lead compounds in relevant cellular models/assays.
Assess glue degrader mechanism of action using established assays.
Elucidate biological mechanisms of action that confer pharmacodynamic effects of lead compounds.
Delineate mechanisms of sensitivity and resistance using chemical and genetic approaches to define desired compound profiles.
Support molecular and cell biology platforms for target identification and validation through plasmid cloning and cell line engineering.
Analyze and document experimental results using Microsoft Excel, GraphPad Prism, and other applicable data systems.
Communicate results and solicit effective input and feedback in a variety of internal settings.
Required Qualifications - MS with 5+ years, or BS with 8+ years of industry experience.
- Proficiency with routine cell and molecular biology techniques including tissue culture, immunofluorescence, qRT-PCR, western blotting, and ELISA.
- Proficiency with BSL2/BSL2+ practices.
- Strong hands-on experience with cell-based assay development, optimization, data analysis, and troubleshooting, including plate-based high-throughput readouts (e.g., luminescence, fluorescence).
- Excellent verbal, written, and interpersonal communication skills.
- Desire and capacity to participate in a dynamic and fast-paced research setting.
- Self-motivation and flexibility, with desire and capacity to work collaboratively as part of a multidisciplinary team.
Preferred Qualifications - Experience with targeted protein degradation.
- Experience with cell line engineering strategies (RNAi, CRISPR, lentiviral transduction).
- Experience with contemporary plasmid cloning techniques.
- Experience with HTS-enabling technologies (e.g., liquid handlers, compound dispensers).
What we offer: - Industry-competitive compensation
- Annual target bonus
- Stock options
- 401K plan
- Career advancement opportunities
- Monthly town halls to share business and scientific updates
Work Hard, Stay Well - Comprehensive medical, dental, and vision plans for employees and their dependents
- Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
- Employee Assistance Program
- 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
- Supplemental pay for Pregnancy Disability Leave
- Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Lifestyle- Casual work environment
- Volunteer days off each year to spend time contributing to causes you care about
- Flexible work schedule
- Access to a state-of-the-art gym
Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
Neomorph is headquartered in San Diego, California.
