Sr. Research Associate / Scientist, MSC Extracellular Vesicles
The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and is focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.
Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.
AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.
Astellas is announcing a Senior Research Associate/Scientist (MSC) Extracellular Vesicle, located in Marlborough, MA.
Purpose & Scope:
Demonstrated potential for creativity and excellence. Candidate will design and conduct novel cell biology and molecular laboratory research and will play a key role in developing hESC-derived mesenchymal stem/stromal cells (MSCs) to treat a wide spectrum of autoimmune an/or neuroinflammatory disorders.
Demonstrated potential for creativity and excellence. Candidate will design and conduct novel cell biology and molecular laboratory research and will develop human pluripotent stem cell (PSC)-derived hepatic progenitors for potential clinical applications.
Essential Job Responsibilities:
- Performs research and/or development in collaboration with others.
- Makes detailed observations, analyzes data and interprets results.
- Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project goals.
- Prepares technical reports, summaries, protocols, and quantitative analyses. Investigates, creates and develops new methods and technologies for project advancement.
- Maintains high level of professional expertise through familiarity with scientific literature and novel technologies.
- Uses professional concepts in accordance with company objectives to solve complex problems in creative and effective ways.
- Conceptual knowledge of innate and adaptive immune cells and immunomodulatory cytokines.
- Hands on experience in extracellular vesicle isolation and characterization of their internal protein, RNA, and/or miRNA contents.
- Solid command of aseptic cell culture procedures, pluripotent stem cell culture differentiation, flow cytometric analysis, qRT-PCR and/or immune-cytochemistry.
This position interacts with all levels of management on a routine basis and influences strategy. Works on complex and diverse problems giving guidance and suggestions. Actions may have implications on operations, budget and/or credibility.
Reports to the Senior Director of Development
- We are seeking a Masters-level and/or PhD (with 0-2 yr of post-doc experience) Sr. Research Associate/Scientist with experience in with exosome isolation. This could be from primary MSCs or other cell types.
- Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals or drug development portfolio
- Ability to collaborate with external partners across multiple scientific disciplines
- Excellent written and oral communication skills are essential.
- Previous hands-on experience in the culture and differentiation of pluripotent stem cells (PSCs) is a plus.
- Previous experience with pluripotent stem cells (hESC/iPSC). hESC-derived mesenchymal stem/stromal cells (MSCs)
The statements above are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time.
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