Senior Scientist

POSITION OVERVIEW

The Rare and Neurologic Diseases Therapeutic Area in Sanofi is seeking highly motivated scientists to identify novel therapies in the field of neurodegenerative disease research.

We are seeking a highly motivated Scientist to join the Neurodegenerative Diseases Cluster located in Cambridge, MA. The successful candidate should have broad knowledge of neurobiology and demonstrated ability to integrate into projects and assignments as part of a dynamic team, contributing technical skills and functional knowledge. The position is a hands-on, laboratory- and bioinformatics-based role. The successful candidate will play a key supporting role in target credentialing for diseases such as Alzheimer’s and Parkinson’s Disease by analyzing cutting-edge bulk and single-cell RNA sequencing data using bioinformatics tools and applications from Bioturing, Qiagen, and other commonly used platforms. The candidate is expected to analyze, record and report data, be able to develop and learn new techniques, and execute multiple projects simultaneously with appropriate supervision. The candidate will participate in new targets identification and validation to support current and future drug discovery programs. This exciting role will afford scientists the opportunity to be intimately involved in early discovery research and pre-clinical development.

KEY RESPONSIBILITIES

• Responsible for independently performing experiments and studies in support of research project for drug discovery goals.
• Initiate, design, direct, and execute experiments, and analyze, interpret, and present results.
• Collaborate with bioinformatics and translational science team to identify and validate the therapeutic targets.
• Analyze bulk and single-cell RNA sequencing data using bioinformatics tools and applications.
• Support drug discovery project working with scientific platform teams and proactively contribute to projects from discovery into early clinical development.
• Support the development of disease relevant in vitro and in vivo models, including establishing in vitro assays to evaluate the biological functions of target molecules in human neural 2D and 3D models.
• Must be well-organized and detail-oriented, with meticulous record keeping and documentation according to Sanofi quality SOPs, capable of working independently with minimal supervision, ability to work productively in a team environment, ability to adapt to changing project priorities and timelines with willingness to learn new techniques.
• Must be able and willing to learn and incorporate new concepts and technologies.
• Prepare publications, research, and clinical/regulatory documentation in accordance with Sanofi quality standards.
• This position requires both bioinformatic analyses and hands-on laboratory bench work and has no direct reports; however, they may have the opportunity to mentor scientists in the Cluster and will be accountable for effective performance of team members.

BASIC QUALIFICATIONS

• PhD in neuroscience, bioinformatics, or related field with at least 3 year of post-graduate laboratory experience OR Master’s degree plus >7 years laboratory experience in an academic or biopharmaceutical setting.
• Familiarity with bioinformatics databases and tools such as R and Python.
• Demonstrated expertise in human neurobiology and pre-clinical neurodegeneration
• Skilled in cell culture and significant experience with with induced pluripotent stem cell (iPSC) culture techniques and functional analysis is preferred.
• Experience designing/evaluating assays for in vitro blood brain barrier (BBB) models (e.g. transwell, chip based) preferred.
• Proficiency across cellular, biochemical, and molecular techniques, which may include stable cell line generation and characterization, protein detection (MSD, Luminex), lipidomics, and gene profiling (RT-PCR, NanoString)
• Excellent written and oral communication skills
• Excellent interpersonal and team skills; Must be both highly collaborative and able to work independently.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SA

#LI-SA

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Please note you are leaving the corporate site of Sanofi and are being redirected to our applicant tracking system, Workday, which allows you to