Senior Scientist/Principle; Upstream Process Development at Applied Molecular Transport Inc. in South San Francisco, CA

Applied Molecular Transport are looking for an experienced Fermentation Scientist to develop, optimize and scale-up upstream processes for the production of biopharmaceutical proteins.

Primary Responsibilities

• Design and execution of experiments to develop and optimize fermentation and primary recovery processes for the production of novel therapeutic proteins.
• Production of small amounts of biopharmaceutical protein for use in pre-clinical studies.
• Collaboration with various teams for the transfer of processes to manufacturing facility.

Required Skills

• Strong technical competency in the scientific principles of fermentation and microbiology.
• Extensive experience in the operation of lab scale fermentation equipment.
• Demonstrated experience of media and process development for fed-batch fermentation including the use of DOE techniques.
• Good working knowledge of E. coli expression systems and related processes.
• Experience with process monitoring and analysis using biological, biochemical, and analytical chemistry assay techniques.
• Competence in data analysis and presentation of experimental results.
• Understanding of regulatory requirements for the development and production of biopharmaceutical products.
• Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
• Attention to detail, safety and good laboratory practices.
• Experience in supervising and mentoring direct reports.

Required Experience

• A PhD degree or equivalent experience in Chemical Engineering or Microbiology or related field.
• At least 4 years of hands-on Industrial experience developing microbial fermentation processes.