Senior Scientist, Metabolism

Pfizer   •  

Cambridge, MA

Industry: Pharmaceuticals & Biotech


11 - 15 years

Posted 168 days ago

This job is no longer available.


The Internal Medicine Research Unit (IMRU) is committed to finding cures for cardiovascular disease, metabolic diseases and related complications.  Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving Nonalcoholic Steatohepatitis (NASH), cachexia, obesity, diabetes and cardiovascular disease.  The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo and in vitro metabolic research models. The scientific focus of this role is to identify critical inflammatory and metabolic pathways in cachexia and NASH with the goal of developing effective therapies.


  • Apply scientific and technical expertise to drug discovery programs to impact the future of new drug candidate development
  • Conceptualize and design experiments
  • Organize and conduct in vivo/ ex vivo/ in vitro studies independently (including preparation, data collection, interpretation, and presentation)
  • Maintain awareness of scientific and technical developments in field
  • Author manuscripts for quality publications in top-tier journals
  • Interface with an interdisciplinary team of scientists in the Internal Medicine Research Unit and engage in both target exploration and driving established projects in our portfolio
  • Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions
  • Maintenance of laboratory notebook records and adherence to safety policies is strictly required


  • PhD with a minimum of 2 years of post-doc experience, BS with 10+ or MS with 5+ years of experience in inflammation research, pharmacology, cell biology, or physiology. 
  • A successful track record of scientific achievements through scientific publications and presentations
  • Deep expertise in cell biology with emphasis on metabolism and signaling pathways is essential. Experience working with various cell types including inflammatory cells is a plus.
  • Experience in performing in vitro, in vivo and ex vivo experiments
  • Candidate should be able to review literature to formulate new ideas, and have the ability to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.
  • The candidate will have daily interactions with a team of creative and innovative scientists in a supportive environment.  Excellent communication and interpersonal skills are essential.