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Senior Scientist, Lead Discovery – Targeted Protein Degradation in San Francisco, CA



$100K - $150K*


Life Sciences


8 - 10 years

Job Description


We are seeking a talented and highly-motivated individual with a background in ubiquitin biology or targeted protein degradation and an interest in drug discovery to join our collaborative team of scientists to greatly expand the toolbox of ubiquitin E3 ligases that can be used for targeted protein degradation. Currently, only a small subset of the >600 E3 ligases are harnessed for this purpose. Using Nurix's DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of novel E3 ligases. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent design, evaluation, and advancement of degrader molecules from these novel E3 binders.

Key Responsibilities

  • Develop rationale for the targeting of specific E3 ligases for use in targeted protein degradation
  • Desig
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Valid through: 2020-3-17

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