We are seeking a highly motivated and talented individual to join the Immunohistochemistry team in the Translational Development Group at Bristol Myers Squibb (Redwood City, CA). The Scientist will be part of a team dedicated to developing various tissue-based technologies to drive discovery programs and enable translational biomarker strategies in multiple oncology programs. The ideal candidate will possess in-depth experience in validating translational immunohistochemistry (IHC) and multiplexed immunofluorescence assays, antibodies, and tissue-based special transcriptomics. He/she will also have strong communication skills, ability to work in a matrixed-based, fast paced environment, solid problem-solving abilities, and a commitment to excellence.
Responsibilities will include, but are not limited to, the following:
- Design, develop, and execute translational immunohistochemistry (IHC) and multiplexed immunofluorescence assays, and tissue-based special transcriptomics biomarker assays to support patient stratification, pharmacodynamics, deciphering the mechanism of action, evaluate efficacy & toxicity, and prediction of clinical response from early discovery to first in human proof of concept.
- Develop and execute tissue-based experiments, including validation of antibodies, in preclinical models.
- Identify and evaluate new technologies to support our evolving biomarker strategies including digital image analysis and deep learning.
- Responsible for overseeing data analyses and delivery of decisional data of CRO-based projects.
- Effectively collaborate in highly matrixed organization to drive advancement of early stage projects into translational and clinical development.
- Act as a technical expert in his/her field and provide guidance for internal collaborators.
- PhD degree with 2-4 years of industry experience applying translational tissue-based technologies for oncology and/or clinical research (industry experience preferred).
- Extensive experience in histology, normal and diseased tissue sample preparation, sectioning (cryostat and microtome), immunohistochemistry, in situ hybridization, and microscopy.
- Extensive experience with chromogenic and fluorescent staining (mono and multiplex) on pre-clinical, non-clinical and clinical samples.
- Expertise with manual/automated microscopy (Bright Field and Fluorescent) and image analysis software and platforms (ex. HALO, Visiopharm etc).
- Tissue culture, flow cytometry, si/shKD and CRISPR-editing skills are preferred.
- Knowledge of tumor pathology, cancer biology and immuno-oncology is a plus.
- Strong track record of developing and implementing strategic initiatives to improve scientific and/or operational activities.
- Experience working with service providers and CROs.
- Excellent organization skills and familiarity with a fast-paced work environment.
- Collaborative spirit and ability to thrive in a matrixed environment.