Senior Research Scientist, Mechanistic Biology & Profiling

AstraZeneca   •  

Waltham, MA

Industry: Pharmaceuticals & Biotech


Less than 5 years

Posted 65 days ago

This job is no longer available.

Discovery Sciences is a multi-faceted department which drives early drug discovery across AstraZeneca's global Research & Development portfolio. Mechanistic Biology & Profiling (part of Discovery Sciences), is a global, multidisciplinary department responsible for mechanism-of-action studies and compound profiling for efficacy and pre-clinical safety in support of the Oncology, Cardiovascular and Renal Disease, Respiratory, Inflammation & Autoimmunity, and Neuroscience portfolios.

If you're inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Main Duties and Responsibilities

Reporting directly to the US Associate Director of the Mechanistic Biology & Profiling Department you will be an integral member of a team generating pre-clinical pharmacology data to predict and understand compound (and novel drug modalities) efficacy.

You will provide early, impactful mechanistic insight to projects across the Oncology and Neuroscience disease areas, through a combination of in vitro enzymology, pharmacology, and quantitative cell biology. You will be a skilled and passionate lab-based scientist, able to represent the department across a range of therapeutic projects and global initiatives, and also externally. You will drive scientific and technical innovation, including through external collaboration and partnership.

Essential Requirements

  • Formal training and proven expertise - PhD and at least 3 years of relevant experience postdoc or industry experience in a quantitative biology-based discipline (enzymology, pharmacology, quantitative cell biology)
  • Significant external reputation in pharmacology and/or enzymology, gained through professional recognition, external presentation and publication in high-impact journals
  • Experience of establishing and leading external collaborations
  • Track record of delivering results across a diverse project portfolio

Desirable Requirements

  • Experience in pre-clinical drug discovery