Senior Principal Scientist, Pharmacokinetics, Dynamics & Metabolism

Pfizer   •  

La Jolla, CA

Industry: Pharmaceuticals & Biotech


8 - 10 years

Posted 45 days ago


Responsible for the oversight of a number of projects within Research Units and providing BioMedicine Design - Pharmacokinetics, Dynamics & Metabolism (BMD-PDM) - focused leadership and strategic direction to assigned projects from early discovery through loss of exclusivity.


  • Identifies key BMD-PDM related project attrition risks and in collaboration with internal BMD stakeholders creates and integrates this risk-mitigation strategy into the overarching project strategy.
  • Ensures execution of the BMD-PDM strategy in partnership with BMD scientists.For example, works with bioanalytical scientists to ensure the appropriate assays, interfaces with biomarker scientists, PK/PD modelers and other biotherapeutic BMD-PDM partners to develop quantitativetranslational pharmacology plans, ensure appropriate PK predictions and dose projection approaches, and develop immunogenicity risk assessment and mitigation strategies.
  • As the BMD-PDM lead to project team(s), the scientist is expected to integrate nonclinical pharmacokinetic, pharmacodynamic and metabolism knowledge, influence the preclinical project plans, and drive optimization of biotherapeutic molecules.
  • The candidate will also advance the science and strategies for prosecuting biotherapeutic projects as well as influence external scientific and regulatory practices through publication and other interactions.
  • Liaises with: Core discipline groups within BMD, and interacts with the Project Leader and scientists in Biology departments, Drug Safety, Pharmaceutical Sciences, and Clinical departments at all stages of discovery and development.


  • PhD with 8+ years of work experience (of which at least 4 years in pharmaceutical industry) in Pharmacokinetics, PK/PD, or relevant field
  • Solid understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental)
  • Working knowledge in the pharmacokinetics and disposition of biotherapeutic modalities.
  • Solid understanding of immunological and other biotherapeutic bioanalytical assays.
  • Good understanding of PK/PD modeling and the application to advance projects from idea to clinical development.
  • Experience integrating data from multiple sources into a rational understanding of absorption, distribution, clearance, PK/PD, and immunogenicity
  • Demonstrated collaborative skills and effective partnering skills in a complex, multi-discipline organizational model.
  • Excellent oral, written, and presentation skills demonstrated through internal and external presentations.
  • Excellent interpersonal relationship skills


  • Experience in the preparation of regulatory applications (IND, NDA, BLA) and good knowledge of regulatory guidelines is preferred