Scientist - Sequencing

Overview

Acuity Spatial Genomics is focused on opening a new frontier in spatial 3D genomics and multiomic analyses. We are committed to the development of a novel technology platform allowing progress in genome-wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. We bring together the premier spatial omics approach, jebFISHTM (building on OligoFISSEQ technology), with leading-edge imaging, data acquisition and analysis capability.

The pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single cell and sub-cellular level.

We aim to find the best talent in the field to join and contribute to this extraordinary, exciting endeavor becoming a critical member of this groundbreaking opportunity. Join us as a key contributor on our journey towards advancing spatial omics approaches at Acuity Spatial Genomics.

We are seeking a dynamic Scientist to optimize and develop advanced bioassays, unlocking the mysteries of chromosome and chromatin architecture.

Collaborating with a diverse team of molecular biology, wet lab, and imaging experts, you will pioneer cutting-edge experiments, mapping spatial gene activity and expression.

As a crucial member of our team, you will lead the way in technique optimization for in situ imaging of gene activity, localization, and expression.

Your demonstrated wet lab expertise and passion for collaborative work in a fast-paced startup environment will drive transformative discoveries.

Bring your exceptional attention to detail, independent laboratory experience in chemistry, biochemistry, or molecular biology, and a can-do attitude to join us on this exciting and purposeful scientific endeavor.

Responsibilities

• Support and spearhead the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation
• Organize and plan late stage, product development activities including buffer optimizations, DOE, stability studies, QC assay development or optimization, data management and documentation management
• Help develop the optimization of sample preparation methods such as tissue/cell fixation and permeabilization
• Independently plan and execute experiments, accurately record details, provide in-depth analysis, and report results through documentation and presentations
• Support the optimization of probe chemistry and probe-based sequencing with spatial multi-omic profiling applications
• Support the generation of test samples through cell culture and/or tissue preparation
• Prepare assay reagents and other components
• Work within multidisciplinary teams at all stages of product development
• Assist with research projects to profile spatial genomics
• Collaborate with other team members on research studies
• Support and lead elements of the development, verification and validation of product related kits and reagents
• Analyze specimens on imaging instrumentation. Analyze research data and assist with data interpretation
• Prepare research reports and share findings with the team. Write protocols, develop procedures, and maintain accurate records
• Clearly communicate and present results; contribute data for making critical design decisions.

Qualifications

• BS/MS/PhD in molecular biology, biochemistry, cell biology, or a related field and 3-6+ (BS/MS) and 0-2+ (PhD) years of hands-on molecular biology experience in an academic or industrial setting
• Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques
• Experience with microscopy
• Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed-based techniques
• Understanding of basic absorption and emission spectroscopy
• Highly motivated with excellent attention to detail
• Good communication (oral and written) and collaboration skills
• Experience in cell culture and tissue preparation techniques
• Experience in troubleshooting and optimization of molecular biology assays including reagent formulation and workflow optimization
• Experience with experimental design and data analysis. Must be capable of performing complex multi-step experiments with detailed and diligent attention to technique and protocols with accurate record keeping
• Desire to be part of a rapidly evolving organization, which requires real-time communication, flexibility, working well with others, and a willingness to learn new techniques and methods.

Additional desirable skills to have:

• Experience in product development including product release
• Familiarity with basic statistical data and error analysis
• Familiarity with single cell and/or spatial transcriptomics, fixation chemistry, Design of Experiments (DOE)
• Advanced fluorescence imaging techniques. Experience in microscopy image analysis

At Bruker, base salary is part of our total compensation. The estimated base salary range for this full-time position is between $100,129 and $158,800 and provides an opportunity to progress as you grow and develop within a role. The base salary for the role will depend on a several job-related factors, including, but not limited to education, training, experience, the geographic location of the successful candidate, skills, competencies, job-related knowledge and travel requirements for this position. Full-time employees may also be eligible for a performance-related incentive in addition to a full range of benefits including 401(k) with company match, an employee stock purchase plan, medical and dental plans, life insurance, short-term and long-term disability insurance, employee assistance program and paid time off including vacation, sick time and holidays, and more.

We are an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, veteran status, and other protected characteristics.

Bruker is a federal contractor and subject to Executive Order 14042. Under Executive Order 14042, all employees must be fully vaccinated against COVID-19 (with limited exceptions for those employees who are unable to be vaccinated due to a medical condition or a sincerely held religious belief). You will need to provide proof of vaccination by submitting a copy of your CDC COVID-19 Vaccination Record Card to Bruker, or obtain areligious or medical exemption, as a condition of employment.

Certain positions at the Company require compliance with export control laws and a result, all interviewed candidates for all positions will be screened pre-interview to determine their eligibility in light of export control restrictions.