Scientist/ Senior Scientist - Single-Molecule Biophysics at 10X Genomics in Pleasanton, CA

About the role:

We are looking for an exceptional, multidisciplinary scientist to drive new research and product development efforts in our Molecular Biology department. The ideal candidate will have a proven track-record in biophysics with extensive experience designing and working with single biomolecule imaging platforms such as DNApaint, dSTORM, or other advanced microscopy techniques. This position also necessitates a deep understanding of molecular biology as you will be applying your skills and knowledge to optimize and evaluate new assays in the area of spatial transcriptomics. Additionally, this role will require you to interact closely with colleagues in several departments including computational biology, software, engineering and microfluidics. You should be driven by developing revolutionary new products and technologies and enjoy working in a fast-paced, innovative and truly multi-disciplinary environment.

What you will be doing:

The successful candidate will contribute biophysics and molecular biology expertise and leadership to cross-disciplinary product development teams to ensure project milestones and technological specifications are met.

Design and execute experiments using novel imaging and biochemistry platforms peripheral to various spatial technology platforms under development at 10x genomics. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups.

Work closely with computational biologists and optical engineers to interpret data generated by novel optical and biochemical assays.

Develop demonstrated and robust protocols that will be used internally across various teams during product development.

To be successful in this role, You need:

• A PhD in Physics, Biophysics, Physical Chemistry, or related field.
• Advanced microscopy skills, with expertise in one or more of the following: Confocal, Epifluorescence, TIRF, Optical tweezers, etc..
• Proven ability to design novel molecular biology assay schemes, as evidenced by peer-reviewed publications, published patents, or commercialized products.
• Strong organizational skills
• Strong written and oral communication skills
• Strong troubleshooting and problem solving skills
• Ability to work in a fast-paced and quickly changing environment
• Desire to build game-changing technologies and impact the world of life science research

Additional desired Skills:

• Experience in spatial biotechnologies is a plus.
• Single molecule imaging of nucleic acids is a plus.
• Skills in image analysis is a plus.