Scientist - Ophthalmology


Bedford, MA

Industry: Biotech/Pharma


Less than 5 years

Posted 283 days ago

This job is no longer available.


Location: Bedford, MA

Job Code: SOP ? 0004-18


Homology Medicines is currently searching for a Biologist with expertise in Ophthalmology to join our team. The successful candidate will help guide a team of researchers and technicians in developing novel gene editing therapies, identifying new areas of research, prioritizing existing projects, and contributing to strategic research plans as it relates to ophthalmology. He/she will guide research projects, including in vitro and in vivo preclinical studies, and transfer work to CROs and service providers as appropriate to progress an ophthalmology portfolio. A successful candidate will have deep experience in utilizing gene editing tools, preferably CRISPR/Cas9 but also TALEN or ZINC Finger Nucleases, plus experience with viral (e.g. AAV, Lentiviral) and/or non-viral (e.g. nanoparticle, liposome) delivery of these tools in vitro and in vivo. Additionally, the candidate will be familiar with various inherited ophthalmic disorders, associated animal models, and have experience managing projects and research teams.

Essential Functions and Duties

  • Lead the development and implementation of a preclinical research plan from discovery to IND/CTA
  • Identify and propose projects to senior management for approval
  • Serve as principal investigator or study director of preclinical studies
  • Collaborate with and serve as scientific mentor to assigned Research Associates, directing the work of research associates at the laboratory bench
  • Develop scientific talent
  • Assist Head of Neurology and Ophthalmology Discovery in prioritizing and allocating resources
  • Leverage external research collaborators as needed
  • Investigate, create, and/or develop new methods and technologies for project advancement
  • Assist in securing intellectual property, including detailed descriptions for patent filing and/or proof of concept work, as appropriate

Skills and Experience

  • PhD + Post-doc in a relevant scientific discipline and 3+ years of industry experience related to genetic engineering and/or ophthalmic research
  • Direct experience with assays and technologies related to gene editing, viral and/or non-viral DNA/RNA delivery
  • Significant knowledge of ophthalmic disorders
  • Excellent oral and written communication skills
  • Ability to work in a team-oriented environment but also be a self-starter, internally motivated, with the ability to work independently to drive the research forward
  • Scientifically rigorous, highly organized, with significant attention to detail
  • Knowledge of the pathophysiology and treatment of ophthalmic disorders and related genetics
  • Prior success discovering and developing successful novel medicines
  • Proven track record of leading research programs and establishing strong collaborations
  • High energy level, focus, a passion and sense of urgency for developing important new medicines for devastating diseases


Homology Medicines, Inc. (HMI) has built foundational intellectual property on gene editing and gene therapy vectors derived from naturally occurring human adeno-associated viruses (AAVs). The Company's technology is precise, on-target and highly efficient for in vivoediting of genetic mutations. This transformative platform technology, combined with an elite leadership team of biopharmaceutical industry veterans, create a significant opportunity for HMI to rapidly advance a diverse pipeline of new medicines that address and potentially cure the underlying cause of genetic diseases.

$100K - $150K