$80K — $100K *
SomaLogic is a privately-owned biomedical science company that developed a revolutionary proteomics technology capable of measuring thousands of different proteins in a single small sample. We are a dedicated team of scientists, bioinformaticians, statisticians, and software developers working to build new tools based on our technology that will change the way life science research is done and healthcare is delivered. Come apply your technical expertise to making healthcare better for your loved ones and the whole world.
The Scientist will have an integral role in our Analytical Sciences Group, working closely with the SOMAmer Discovery Group, contributing to the biophysical, chemical, and functional characterization of SOMAmer® reagents, which are modified DNA affinity reagents. The ideal candidate will focus on using their mass spectrometry-based proteomics skills to help characterize the specificity of our reagents with respect to their protein targets. Level commensurate with experience.
Key Job Responsibilities:
Build and optimize a toolbox of methods and analytical schemes to characterize the specificity of SOMAmer reagents, using industry standard mass spectrometry-based proteomic methods. This set of tools includes:
o robust, high throughput methods to be applied across a large group of reagents for confirmation of binding to target proteins, cross-reactivity to related proteins, and initial survey of nonspecific (off-target) protein binding
o specialized characterization methods (e.g. characterization of PTMs and biological networks, and enrichment/depletion experiments) to be applied to smaller groups of reagents
Provide analytical support for continuous improvement of our proteomics assay
Train and mentor other laboratory personnel to conduct lower level analyses
Research approaches for method qualification and validation
Degree in Chemistry, Biochemistry or related field. Ph.D. with 0-4 years, Master’s degree with 10+ years, or Bachelor’s degree with 12+ years of relevant experience
Skills and experience
Strong skills in all aspects of mass spectrometry-based proteomics, including sample preparation, method development, analysis, database searching, and data analysis
Experience in enzymatic digestion of proteins
Familiarity with enrichment and depletion methods
Experience with peptide labeling reagents such mass tags
Publications in the field of proteomics
Experience with Waters QTof mass spectrometers and software packages (e.g., Progenesis) a plus
Experience with PAGE analysis of proteins and other basic/common biochemical techniques
Strong attention to detail
Excellent written and oral communication skills
Work is in both a typical office environment and in a typical laboratory environment with personal protective equipment use required.
Extended keyboarding time is required.
Must be able to lift 30 lbs and move liquid and gas cylinders
Valid through: 6/25/2021
$100K — $150K *
4 days ago
$100K — $150K *
4 days ago