The Biology department at Calithera Biosciences is seeking a highly motivated scientist to help identify novel biological targets for small-molecule cancer therapy. The ideal candidate will utilize their working knowledge of cancer biology to identify and interrogate novel drug targets, biological pathways, and associated tumor types that may be amenable to intervention with small-molecule therapeutics. The position requires a strong understanding of cancer biology and/or cancer genetics, and experience in biological target identification and chemical lead identification. The ideal candidate will also have a working knowledge of the drug discovery/development process.
Calithera Biosciences is a publicly traded company focused on discovering and developing small-molecule drug candidates directed at first-in-class targets for the treatment of cancer. Our lead product candidate, teleglenastat (CB-839), is an internally discovered first-in-class inhibitor of glutaminase, a critical enzyme in tumor metabolism. Calithera also has an active clinical and pre-clinical research pipeline committed to discovering the next generation of cancer therapeutics.
Duties and Responsibilities
- Utilize available resources to identify and prioritize novel biological targets for cancer therapy.
- Independently formulate and test hypotheses on the role of biological targets in tumor biology using genetic and pharmacologic tools.
- Develop quantitative, target-specific biochemical and cell-based assay suitable for high-throughput screening of small-molecule libraries.
- Support lead-optimization efforts with enzyme, biochemical and cell-based assays.
- Manage and mentor junior employees.
- Manage research collaborations with external CROs.
- PhD in chemical biology, cancer biology, biochemistry, biophysics, bioinformatics, cell biology or related discipline with 0 - 2 years post-doctoral or pharma/biotech experience is required.
- A deep understanding of biological pathways that underlie the cancerous phenotype is required.
- Demonstrated hands-on experience in the use of genetic methods for biological target interrogation (CRISPR, shRNA, siRNA) is required.
- Demonstrated hands-on experience in designing, executing and analyzing biochemical and cell-based mechanism of action experiments is required.
- Experience in developing quantitative biochemical or cell-based assays to support HTS or small-molecule lead optimization efforts is highly desirable.
- Experience designing and executing high-throughput genetic, chemical-genetic, or synthetic lethality screens is highly desirable.
- Creativity, good communication, and excellent interpersonal skills are required.
- Breadth and flexibility to adapt to changing project needs.