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The University of Washington (UW) is proud to be one of the nation's premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service.
The Freedman Lab in the Division of Nephrology, Department of Medicine, is seeking a Research Scientist (Research Scientist/Engineer 3 (E S UAW RSE)) to lead projects using human pluripotent stem cells to develop new treatments for kidney disease, under the general guidance/supervision of Associate Professor Benjamin Freedman. The Research Scientist will combine stem cell culture and differentiation with bioengineering, microfluidics, and pre-clinical animal models to build next-generation models of human kidney regeneration and disease. This position will be responsible for contributing to preparation of reports, papers, presentations and new proposals. He/she will contribute to positive colleague and investigator relationships through interactions on current grants. The successful applicant will also assist Dr. Freedman with mentoring of trainees. Experience with animals is a plus.
This position will be located at South Lake Union campus of UW Medicine, a bastion of stem cell research in the innovative center of Seattle. The successful candidate will be detail-oriented, reliable, highly organized, possess a high degree of accountability for quality of work performed, can work independently and has excellent technical skills.
DUTIES AND RESPONSIBILITIES
Experimental duties include: 60%
Animal work - husbandry, injection, analysis and surgery relevant to kidneys
Cell culture - daily differentiation and maintenance of human pluripotent stem cells
Microscopy - immunofluorescence, confocal, wide-field, live cell
Microfluidics - bioengineering, device preparation, input/output bioanalysis
Genome editing - guide RNA construction, transfection, screening
Drug discovery - design and execution of high throughput screening assays
Biochemistry and molecular biology - qPCR, electrophoresis, immunoblotting, cloning
Computing and analysis - Illustrator, Powerpoint, Excel, Word, ImageJ, HTML
Documentation - daily record of work performed in files and laboratory notebook
Lab duties: 20%
Mentor research trainees and undergraduates; contribute to improvements in efficiency
Orient/train new staff
Manage projects of moderate size and scope
Assemble and organize research teams
Lead projects or project tasks toward research objectives
Inventory management for reagents/orders/cells; track expenses
Ensure compliance with lab regulations and completion of corresponding paperwork
Scholarship: 10%
Contribute data and ideas for new projects
Drafting of new grants with minimal supervision
Preparation of primary research manuscripts with minimal supervision
Writing invited manuscripts
Assist in seeking/acquiring additional funding
Manage relationships with grants sponsors and progress reports
Animal care includes: 10%
Data collection/maintenance management for rodent colony
Updating and ensuring compliance with animal welfare protocols
Oversight of junior trainees working in the animal facility
Demonstration and training of surgeries
Developing new animal protocols
MINIMUM REQUIREMENTS
Bachelor's degree in biology, bioengineering, biophysics or related field and at least four years of experience or equivalent combination of education and experience.
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
ADDITIONAL REQUIREMENTS
Cell culture skills and experience; strong computer skills including Excel, statistical and/or graphical software (ex. Adobe Illustrator, ImageJ, Powerpoint); excellent organizational and communication skills; ability to manage diverse tasks; flexibility in work hours; a thirst for scientific knowledge and progress; comfort working with animal model; and a high degree of integrity.
DESIRED QUALIFICATIONS
Experience with human pluripotent stem cells, high throughput screening, genome editing (CRISPR/Cas9), or rodent microsurgery.
Application Process: The application process may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are access ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
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Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.
To request disability accommodation in the application process, contact the Disability Services Office at [redacted] or [redacted].
Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.