The Research Scientist will join the Integrated Oncology Discovery Research team at Bristol-Myers Squibb in Redwood City, CA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to support and advance preclinical drug discovery programs. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate a knowledge of mechanisms of tumor resistance to immunotherapy and a clear understanding of principals of target identification and validation, professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
The primary responsibilities for this role include evaluation of cancer cell associated mechanisms of immune suppression and the effectiveness of therapeutic molecules using in vitro and in vivo immunological assays
- A B.S. with a minimum of 7 years of experience, or an M.S. with a minimum of 4 years of academic/industrialexperience with a strong scientific background and research experience in immune-oncology is required.
- Hands on experience with a wide range of in-vitro cellular, biochemical and immune assays (ELISA, MSD, Western blot), including isolation, culture and differentiation of human/mouse immune cell populations, MLR, T-cell proliferation assays, MDSC suppression assays.
- Experience with multicolor flow cytometry (10-14 colors) and cell sorting, including characterization of intra-tumor immune cell populations in mouse syngeneic tumors is required
- Good knowledge of cell engineering technologies, siRNA/shRNA knockdown, CRISPR-mediated genome editing, lentivirus generation and transduction of primary immune cells is required.
- Demonstrated leadership skill, independence in the experiment design, execution, data interpretation, troubleshooting and analysis of a scientific literature are required.
- Ability to mentor more junior scientists and colleagues on best practices in the laboratory would be highly valued.
- Attention to detail with excellent organizational and record keeping skills is a requirement.
- Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.
- Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
- This position is located in Redwood City, CA. There will be less than 10% travel.