Research Fellow in Boston, MA

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Posted 7 weeks ago

The WheelerLaboratory in the Center for Genomic Medicine at the Massachusetts GeneralHospital, Harvard Medical School, is seeking a highly motivated post-doctoralfellow candidate to lead a project studying the pathogenesis of X-linkedDystonia Parkinsonism (XDP).


TheWheeler Laboratory studies Huntington's disease and other neurodegenerativedisorders caused by unstable microsatellite repeats, with a focus on mechanismsunderlying the instability of the causative mutations. Recent findings that XDPis associated with a polymorphic hexanucleotide repeat tract (Bragg et al., 2017,PNAS 114(51):E11020-E11028)place XDP in this classof microsatellite expansion disorders. This is an exciting project that wouldbe carried out in close collaboration with Dr. Laurie Ozelius of theMassachusetts Institute for Neurodegenerative Disease (MIND) and a community ofinvestigators of the MGH Collaborative Center for XDP (CCXDP), involving molecular analyses of the XDP repeat andgenetic modifier studies in patients and in iPSC-based models. The position atthe Massachusetts General Hospital/Harvard Medical School, together with closeaccess to the Broad Institute and resources in the Boston area and offerunparalleled opportunity for research in a stimulating and highly collaborativetraining environment at the forefront of human genetic disease research. Thenew hire will be appointed as a Research Fellow at the Massachusetts GeneralHospital and Post-Doc at the Harvard Medical School.


PRINCIPALDUTIES AND RESPONSIBILITIES:

  • Genome engineering using CRISPR-Cas9 editing
  • Human iPSC culture and neuronal differentiation
  • Performing molecular and genetic analyses in patient tissues and cells
  • Developing novel methodologies, including single cell-based methods, for refining molecular/genetic analyses
  • Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports
  • Disseminate results via conferences and journal publication


SKILLS & COMPETENCIESREQUIRED:

  • Theideal candidate should have received (or expect to receive soon) a Ph.D. ingenetics, neurobiology, molecular/cellular biology or related discipline.
  • Highlymotivated, versatile and collaborative, with the abilityto work in a fast-paced environment, and adaptability to new innovations andshifting priorities
  • Astrong record of productivity as evidenced by publication in peer-reviewed scientificjournals
  • Excellent English verbal and written communication skills
  • The ability to independently conduct hypothesis-driven research
  • The ability to work effectively as part of a collaborative team
  • Excellent quantitative and organizational skills
  • Highly skilled in molecular biology techniques
  • High level of competence in statistical analyses
  • Experience in Bioinformatic analyses is a strong plus
  • Experience with growing and manipulating iPSCs is preferred



Interestedapplicants should submit their CV and contacts for references to: Dr. VanessaWheeler at Wheeler@helix.mgh.harvard.edu


Qualifications


KILLS & COMPETENCIES REQUIRED:

  • The ideal candidate should have received (or expect to receive soon) a Ph.D. in genetics, neurobiology, molecular/cellular biology or related discipline.
  • Highly motivated, versatile and collaborative, with the ability to work in a fast-paced environment, and adaptability to new innovations and shifting priorities
  • A strong record of productivity as evidenced by publication in peer-reviewed scientific journals
  • Excellent English verbal and written communication skills
  • The ability to independently conduct hypothesis-driven research
  • The ability to work effectively as part of a collaborative team
  • Excellent quantitative and organizational skills
  • Highly skilled in molecular biology techniques
  • High level of competence in statistical analyses
  • Experience in Bioinformatic analyses is a strong plus
  • Experience with growing and manipulating iPSCs is preferred



EEO Statement


Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.