Less than 5 years
Posted 163 days ago
Our team, led by Dr. Ramnik Xavier, aims to understand the determinants of mucosal tolerance and immunity. To this end, our lab is using a combination of physiologically relevant cell-based assays, genome editing, novel mouse models, and computational analyses.
We are looking for postdoctoral associates to identify the components of the innate and adaptive immune systems that interact dynamically in human health and disease.
Current projects include:
(1) generate novel mouse models to uncover mechanisms of pathogenesis by inducing inflammation using infectious, non-infectious, and immune cell transfer models;
(2) perform functional genomic screens to place disease-associated genetic variants in pathways;
(3) examine the interactions between host genetics and the microbiome during inflammation; and
(4) determine the role of novel autophagy genes in antibacterial defenses in vivo, as well as characterizing cell-specific functions of those genes.
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