Not Specified years
Posted 55 days ago
Req ID: 25098
Employment Status: AF - Active - Regular - Full Time
The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, DVM, etc. and will, under the direction/guidance of a mentor (principal investigator), assume responsibility research in our translational research laboratory focused on developing therapies for pediatric epilepsy and neurogenetic disorders. The primary focus of the lab is to improve our understanding of how genetic disorders that disrupt brain development and function alter the electrical activity of the brain and lead to the clinical symptoms that these children present with. The lab uses a variety of techniques, both physiological, molecular, and genetic, to reach our goal. With these techniques, we aim to address our ultimate goal to develop drugs that not only correct the cellular and molecular defects but also improve the function of electricalcircuits in the brain to treat symptoms such as seizures, autism, and intellectual disability.
The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
We are looking for an individual with experience in cellular physiology and imaging. Prior experience with in-vivo recordings, patch clamp electrophysiology and/or sharp electrode recording is required. The person must have experience in studies on animal models of disease (mouse models). The person must be able to perform appropriate quantitative analysis of the physiological signals. Experience in immunohistochemistry, western blotting, genotypic, and generating targeting constructs is a plus.
We are looking for a person who is bright, intellectually curious, and motivated to both learn new techniques and to apply the skills described above to our work. There are a number on going projects in the lab that the individual will take primary responsibility for but will also be allowed to develop a related research project.
Our lab currently consists of 2 post-doctoral fellows, 2 research assistants, and a number of students and residents.
Required Education and Experience
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Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.