Protein Engineer, Senior Scientist / Scientist

Merrimack Pharmaceuticals   •  

Cambridge, MA

Industry: Pharmaceuticals & Biotech


Not Specified years

Posted 167 days ago

This job is no longer available.

Position Summary:

Merrimack Pharmaceuticals is looking for a highly-motivated scientist/senior scientist to join the Merrimack’s Protein Engineering Team.  We are looking for a candidate who thrives in an interdisciplinary environment and is not afraid of challenges. The ideal candidate is a good communicator, self-motivated, open to change and brings an innovative mindset.  The individual will be contributing to multiple aspects of protein therapeutic drug development from conception and discovery to lead optimization.


  • Expression, purification, and characterization of protein reagents and therapeutics including antibodies.
  • Optimization of leads by humanization and affinity maturation
  • Antibody library construction and screening
  • Generation of murine proof of concept molecules
  • Interact/collaborate on a daily basis with a team of interdisciplinary scientists (in vitro and in vivo biologists, formulation scientists, and computational modellers) within Merrimack and with external collaborators.
  • Engage colleagues in cross-disciplinary scientific discussion regarding preclinical activities such in vivo efficacy studies, mechanism of action studies, biomarker development and disease indication.
  • Effective communication of data results and conclusions, both written and in oral presentations.
  • Staying abreast of relevant scientific methodologies and literature


  • Ph.D. and/or post-doctoral fellowship in protein biochemistry or related discipline
  • Extensive experience in mammalian protein expression, protein purification, and biochemical/biophysical characterization is required
  • Familiar with kinetic characterization of proteins using BLI or SPR
  • Experience in antibody phage or yeast display is required
  • Experience in antibody humanization and affinity maturation is a plus
  • Good understanding of structure function studies with basic knowledge of protein visualization software such as but not limited to Pymol, Chimera and SwissPDB viewer
  • Demonstrated interest in innovative therapeutic design and advancing protein engineering
  • Excellent work ethic, communication and teamwork skills, and desire to work on complex problems in a fast-paced environment
  • Passion for outthinking cancer.