Principle Scientist

Salary depends on experience
Posted on 05/21/18
Gaithersburg, MD
8 - 10 years experience
Pharmaceuticals & Biotech
Salary depends on experience
Posted on 05/21/18

Responsibilities

  • Oversee the scientific projects with the down stream process group.
  • Development of scalable chromatographic techniques for the purification of protein candidates.
  • Consolidation of purification steps for the construction of purification processes.
  • Optimization and scale-up of purification processes for transfer to a contract manufacturing organisation for GMP manufacture.
  • Assist in the technical transfer of purification processes to a relevant CMO.
  • Invention of suitable in-process controls in order to follow the purification process.
  • Generation of technical documents capturing the construction of purification processes.
  • Technical review of draft batch manufacturing records.
  • Generation of draft IPC protocols.
  • To perform intellectual property sign-off and scientific review of Emergent generated data.
  • To communicate ideas and experimental designs with colleagues and manger.
  • To monitor and communicate progress and highlight delays or potential risks to project timelines.
  • To report on progress on a regular basis, both within the downstream group and other vaccine programme teams.
  • Actively train other members of the process development and manufacturing team in purification techniques.

Job Resquirements

  • PhD in Biochemistry or related field with a minimum of 8 years experience.
  • In-depth knowledge of purification and filtration techniques.
  • Experience of working at both lab and manufacturing scale.
  • Knowledge of fermentation (eukaryotic and prokaryotic systems) and analytical techniques.
  • Ability to solve complex and varied problems independently
  • Experience with analytical data analysis.

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