Principal Scientist - Medicinal Chemistry

Alkermes   •  

Waltham, MA

Industry: Biotech/Pharma


8 - 10 years

Posted 395 days ago

Job Description: 

  • As a senior medicinal chemist have the ability to drive compound design inside a chemistry team for a given project directed toward successful project progression and candidate drug delivery

    • Includes responsibility for setting and maintaining the highest scientific standards in drug design activities

    • Ensure an optimal level of engagement with all relevant disciplines e.g. chemistry, biology, DMPK, safety, etc.

    • Evaluates scientific or technical opportunities, while targeting optimal results

  • Seeks external benchmarks for functional excellence

  • Reaches beyond immediate knowledge to influence results

  • Determines next steps even with complex or ambiguous data

  • Help contribute and expand Alkermes’ culture of “hypothesis driven” science
  • Establishes consistency in solving complex, technical problems

  • Creates and tests complex hypotheses

  • Drives technical course of a project area

  • Demonstrates situational leadership and creative problem solving

  • Analyzes specific or unique situations and data, requiring in-depth evaluation

  • Be a scientific and strategic resource for local chemistry management as relates to new ways of working in medicinal chemistry

  • Drive progress and implement improvements in medicinal chemistry for the design and delivery of candidate drugs

    • Ensure robust hypotheses for all proposed molecules

    • Work closely with computational chemistry to implement relevant predictive models to aid in the design of new compounds

    • Explore new applications for data analysis to assist in hypothesis driven compound design

    • Foster a close collaboration with synthetic chemistry to enhance design through synthesis

  • As chemistry lead, assist project leader in the development of strategic, scientific, and technical strategies for a given project

  • Initiate and manage external collaborations to enhance internal projects, capabilities and company recognition

  • Help drive relevant publications strategy and delivery
  • Successfully establish new projects and/or new scientific initiatives

  • Be a role model in behaviors for Alkermes’ way of working

  • Act in accordance with all Alkermes’ policies for personnel, EHS, etc.


Minimum Education & Experience Requirements: A Ph.D. with at least 8+ years’ pharmaceutical experience and an accomplished track record of delivery for drug discovery projects


Technical Expertise Requirements: 

  • Recognized expert in modern medicinal and synthetic chemistry approaches and principles that contribute to successful delivery of drug discovery projects

  • Led programs that delivered compounds into the clinic

  • Lead author on scientifically reviewed publications

  • Presented at professional conferences

  • Managed chemistry teams of 4 or more people including Ph.D. scientists

  • Inventor on published patents

  • Understanding of overall drug discovery process and how to impact from medicinal chemistry perspective

  • Strong technical communication and collaboration skills

  • Effective leadership skills

  • Effective communication skills i.e. must have ability and judgment to communicate appropriate information

  • Able to propose and implement scientific ideas


Personal Attributes Needed: Excellent interpersonal, leadership, communication, and time-management skills are essential


Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, color, religion, sex, sexual orientation, gender expression and identity, national origin, ancestry, age, mental and physical disability, genetic information, any veteran status, military status or application for military service, or membership in any othercategory protected under applicable law.