Principal Scientist, HTS Assay Development, Screening

Johnson & Johnson   •  

Spring House, PA

Industry: Biotech/Pharma


8 - 10 years

Posted 301 days ago

This job is no longer available.

Roles and Responsibilities:

  • Lead the design and implementation of screening strategies that reflect the pharmacology to be modulated in subsequent hit-to-lead discovery programs.
  • Provide scientific leadership to a team that (1) develops assays in cell based formats that are suitable for automated high-throughput screening in 384 or 1536-well formats (2) executes high-throughput screens (3) analyzes screening data including presentation at program team meetings. A level of hands-on laboratory work is expected.
  • Provide mentoring and career development leadership to direct reports and to others within the department as appropriate.
  • Collaborate across multiple therapeutic and functional areas in the US, Europe and Asia.
  • Develop innovative approaches to screening and hit triage.
  • Attend in-house seminars and external scientific meetings as appropriate.
  • Manage external collaborations.
  • Publish research in high-quality journals as appropriate. 


  • A miniumum of a PhD in biochemistry, biophysics, cell biology, pharmacology or related areas is required
  • Postdoctoral experience is preferred
  • A minimum of 8 years of industry experience in assay development HTS is required
  • Expertise with assay development using biochemical and/or biophysical methods is required
  • Expertise with biochemical methods such as FP, HTRF, luminescence and SPA OR an expertise with biophysical methods such as SPR, thermophoresis, ITC and mass spectrometry is preferred 
  • Fragment screening experience is preferred
  • Hit triage experience is preferred
  • Previous people management experience (supervising, coaching, mentoring) is required
  • Publications in high-quality peer-reviewed journals are required
  • Expertise in cardiovascular, immunology, infectious diseases, neuroscience or oncology therapeutic areas is preferred 
  • Experience working with and guiding external collaborators in industry or academia is preferred

Requisition ID: 9073170206