Principal Scientist - Discovery Immunology

Alkermes   •  

Waltham, MA

Industry: Biotech/Pharma


15+ years

Posted 393 days ago

Position Description:  Alkermes is searching for a highly talented immunologist for a permanent position in the Discovery Immunology research group. The ideal candidate will be experienced in innate immunology and conducting in vitro model systems to demonstrate the mechanism/efficacy of proprietary Alkermes biologics and small molecules.  The candidate should be comfortable working in a fast-paced, team-oriented environment. 


  • Responsible for identifying/performing appropriate experimental in vitro systems to demonstrate mechanism/efficacy of proprietary therapeutics

  • Participate in multi-disciplinary drug discovery team and serve as innate immunology resource

  • Participate in advancing Alkermes pipeline and capabilities

  • Communicate key results in written and oral presentations to peers and supervisors


  • Strong understanding of immune system function and dysregulation

  • Experience with innate immune cell biology and functional assays, particularly macrophage biology

  • Experience with in vitro co-cultures modeling fibrosis and/or immune-oncology

  • Experience with gene expression and analysis platforms

  • Comfortable designing, testing, and analyzing multi-parameter (>10) flow cytometric assays (proficiency with LSRFortessa and FlowJo software)

  • Experience with various immune cell isolation techniques, including cell sorting

  • Additional experience in standard molecular and cell biology techniques a strong plus (mammalian cell culture, transfection, SDS-PAGE, ELISA/MSD, qPCR)


  • Ability to rapidly learn and apply techniques

  • Ability to independently design, execute, and analyze experiments

  • Sense of urgency (self-motivation)

  • Strong interdisciplinary communication skills

  • Flexibility


  • PhD with 8+ years or MS with 15+ years of experience in a biotechnology or pharmaceutical setting. Candidates with innate immunity, preferably macrophage biology and fibrosis is preferred.