Principal Scientist, Cell Sciences

Alkermes   •  

Waltham, MA

Industry: Biotech/Pharma


15+ years

Posted 393 days ago

Position Description:

Alkermes has an excellent opportunity for a highly talented cell biologist to lead and build our Cell Sciences group within Cell & Molecular Pharmacology.  The ideal candidate will be experienced with phenotypic screening and mechanism of action studies using state-of-the-art techniques such as deriving cells from human iPSCs, CRISPR-Cas9 genome editing, and 3D cell models (spheroids, organoids), particularly in CNS diseases.  The candidate should be comfortable working in a fast-paced, team-oriented environment.



  • Lead a Cell Sciences group of scientists performing in vitrodrug discovery in human disease-relevant cells
  • Manage the generation and maintenance of human disease-relevant cells by internal development or through vendors/CROs
  • Participate in multi-disciplinary drug discovery teams and serve as a cell biology resource
  • Responsible for running phenotypic screens for CNS drug discovery and performing mechanism of action studies using cellular and genetic approaches
  • Communicate key results in written and oral presentations to peers and supervisors



  • Proficient in the generation and maintenance of iPSC-derived cells and/or spheroids or organoids
  • Familiar with genomic editing techniques such as CRISPR-Cas9, especially as it applies to mechanism of action studies
  • Experienced with medium to high throughput cellular imaging platforms and high content screening
  • Knowledgeable of CNS diseases, particularly pain and psychotic disorders



  • Ability to rapidly learn and apply techniques
  • Ability to independently design, execute, and analyze experiments
  • Sense of urgency (self-motivation)
  • Strong interdisciplinary communication skills
  • Flexibility (tolerate changes in priorities/directions)



  • PhD with 8+ years of experience or MS with 15+ years of experience in a biotechnology or pharmaceutical setting. Candidates with a degree in a relevant scientific discipline (neurobiology or cell biology) and experience in CNS disease drug discoverypreferred.