The Laboratory of Molecular Immunology, headed by Dr. Warren J. Leonard of the DIR, NHLBI, is recruiting for a postdoctoral researcher to work in the area of molecular immunology. Having previously discovered that mutations in the common cytokine receptor ? chain, ?c, result in X-linked severe combined immunodeficiency in humans and that ?c is a shared component of multiple cytokine receptors, the lab focuses on the cytokines that share ?c (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21), as well as the IL-7-related cytokine, TSLP. The laboratory has generated valuable transgenic and knockout mice and a wealth of other valuable reagents. The laboratory encompasses projects ranging from elucidating physiological and disease mechanisms to signal transduction, molecular mechanisms of gene regulation, and epigenetic mechanisms. State-of-the-art methodologies are used in human and murine systems, including in vitro and in vivo approaches, including ChIP-Seq, RNA-Seq, ATAC-Seq, as well as whole exome and whole genome methodology.
The ideal candidate will have a reasonable level of independence, be innovative and interactive, and will have a strong background in immunology and/or molecular biology. The candidate must have received a Ph.D. and/or an M.D. degree. The candidate will be supported with the excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.