A postdoctoral position is available in the Department of Early Discovery Biochemistry to develop peptide-based inhibitors of targets of therapeutic interest and investigate their mechanism of action by biochemistry, structural and cell biology approaches. The group utilizes a multidisciplinary molecular approach for lead identification and target validation. Recent efforts focus on the use of phage display to develop peptide-based probes for modulating protein-protein interactions, the development of cell permeable peptides and characterization of their cellular trafficking routes, as well as new targets in cancer biology and ophthalmology.
Successful candidates will be highly motivated to work independently in a collaborative environment. Candidates must have a Ph.D. in biochemistry, cell biology or related discipline. Candidates should have experience in protein chemistry, cellular biochemistry and state of the art molecular biology techniques as demonstrated by a first-author paper published or accepted in a peer-reviewed journal. A strong quantitative background and demonstrated expertise in recombinant protein expression and purification, protein engineering, analytical and biophysical methods, bioconjugation reactions, and phage diversity methods is desirable. Experience with tissue culture, cell-based assays and transfections, gene knockdown, gene expression analysis and fluorescence microscopy is a plus. The candidate must have strong analytical, collaborative, communication and organizational skills.
Job ID: 201805-106897