Saint Louis, MO
Not Specified years
Posted 240 days ago
A postdoctoral position is available in the laboratory of Dr. Charles Harris in the Division of Endocrinology, Metabolism & Lipid Research at Washington University School of Medicine. Work from the laboratory has focused on the mechanism of glucocorticoid action in metabolic disease. This has been done using mouse models with alterations to the glucocorticoid receptor (GR) including tissue specific knockout mice, mice with point mutations in GR that skew downstream GR effector arms. We are now beginning studies on the role of the mineralocorticoid receptor in metabolic syndrome. While the primary site of mineralocorticoid action is the kidney, more recent studies have demonstrated important roles for this receptor in the heart and immune system. We currently have the mouse lines necessary to generate the needed models in order to probe the role of the mineralocorticoid receptor in metabolic disease. Additional studies in the laboratory relate to the role of GR phosphorylation in vivo using mice with GR point mutations in phosphorylated residues. This position will provide an opportunity to use biochemical, pharmacological, molecular and genetic techniques in animals, along with use of cell culture methods.
PRIMARY DUTIES AND RESPONSIBILITIES:
Prior research experience in nuclear hormone receptors, glucose or lipid metabolism, or related fields.
The hiring range for this position is commensurate with experience.