The Laboratory of Genome Architecture and Dynamics studies how the three-dimensional architecture of the genome reflects and regulates DNA-based processes, with a focus on short-range contacts and biophysical mechanisms of transcriptional silencing. By developing integrative models of the molecular interactions that regulate access to the genome, we hope to understand and rationally manipulate changes in chromatin architecture and gene expression during differentiation and cell reprogramming, in transitions between growth, quiescence and senescence, and in the dysregulated cellular states found in cancer. We use mammalian cell lines as model systems. Our approaches include sequencing-based genomic assays such as RICC-seq and ATAC-seq, biochemistry, microscopy and modeling. We are also actively developing new methods for probing chromatin architecture in intact cells. We will be housed in the new River Campus of Rockefeller University and be part of a vibrant research community with excellent research support including more than 12 core facilities. The Rockefeller University provides excellent housing options for postdocs in Manhattan. Please see www.riscalab.org for more information.
Multiple postdoctoral scholar positions are available in areas including development of next-generation methods for in situ chromatin structure mapping, extending RICC-seq to new model systems such as yeasts or plants, modeling chromatin fiber conformations at the oligo-nucleosome scale, exploring the biophysical mechanisms involved in transcriptional repression in mammalian cells, and studying the relationship between chromatin structure and exit from the cell cycle.
With mentorship from the Head of Lab, postdocs are expected to develop their own line of research that is based on their interests and is compatible with the broad scientific scope of the lab. They will also help build a lab at the intersection of cutting-edge epigenomics and biophysics and help to train and supervise junior lab members including graduate students and research assistants. As founding members, they will have a major impact on the culture of the lab and will have extensive interactions with the Head of Lab.
The candidate must be a self-driven and rigorous scientist who is passionate about chromatin biology, is proficient in quantitative data analysis, and can work in an interdisciplinary, collaborative environment. A successful Ph.D. in a relevant area (including molecular or cell biology, biophysics, biochemistry, chemistry, physics, applied mathematics, bioengineering) and a first-author or co-first-author publication in a peer-reviewed journal are required. Previous experience with genomics, protein biochemistry, biophysical modeling, genome editing or quantitative microscopy is desirable.