Postdoctoral Fellowship in Genome Editing for Sickle Cell Disease

St. Jude Children's Research Hospital   •  

Memphis, TN

Industry: Healthcare


Not Specified years

Posted 276 days ago

This job is no longer available.


The Tsai, Weiss, and Miller Laboratories are seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship to develop potentially curative strategies to treat sickle cell disease by CRISPR-Cas gene editing of human hematopoietic stem cells.


You will have the opportunity to lead new projects such as:

  • Optimizing pre-clinical CRISPR-Cas gene editing strategies for induction of fetal hemoglobin in red blood cell progeny of edited human hematopoietic stem and progenitor cells
  • Developing improved genomic methods to define and measure genome-wide activity of gene editing nucleases
  • Protein engineering of CRISPR-Cas nucleases for precise gene correction

In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.

Minimum Education

Successful applicants will have a strong publication record, excellent communication skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, hematology, or a related area. To succeed in this position, you will have a strong molecular and cell biology background, with an emphasis on molecular cloning and genetic manipulation of mammalian cells. Applicants with experience with human hematopoietic stem cells, genome editing, next-generation sequencing, or automated liquid handling are strongly encouraged to apply.