Principal duties and responsibilities
The Wein laboratory investigates molecular mechanisms controlling the development and function of osteocytes, cells with a central role in orchestrating bone homeostasis. We employ wide-ranging techniques to study osteocyte biology in vitro and in vivo.
A major focus of the laboratory is to understand the intracellular signaling system used by parathyroid hormone (PTH) on osteocytes. These studies will lead to an improved understanding of skeletal responses to PTH, and have important implications for the treatment of osteoporosis and chronic kidney disease.
Education and experience required
- The ideal candidate will have a PhD, MD, or MD/PhD in biomedical sciences, with experience in cell culture, molecular/cell biology, biochemistry, and mouse models of disease.
- This position offers an excellent opportunity to learn and apply skills in osteocyte biology, endocrinology, CRISPR/Cas9-mediated genome editing, signal transduction, phospho-proteomics, epigenetics, and molecular/cellular biology techniques. A strong background in one or more of these areas is preferred.
- Qualified candidates should be able to work independently as well as in a group environment.